Future prospects in mRNA vaccine development

Londiwe Simphiwe Mbatha; Jude Akinyelu; Fiona Maiyo; Tukayi Kudanga

doi:10.1088/1748-605X/aceceb

Future prospects in mRNA vaccine development

Biomed Mater. 2023 Aug 17;18(5). doi: 10.1088/1748-605X/aceceb.

Authors

Londiwe Simphiwe Mbatha¹, Jude Akinyelu², Fiona Maiyo³, Tukayi Kudanga¹

Affiliations

¹ Department of Biotechnology and Food Science, Durban University of Technology, PO Box 1334, Durban 4000, South Africa.
² Department of Biochemistry, Federal University Oye-Ekiti, Ekiti state, Nigeria.
³ Department of Medical Sciences, Kabarak University, Nairobi, Kenya.

PMID: 37589309
DOI: 10.1088/1748-605X/aceceb

Abstract

The recent advancements in messenger ribonucleic acid (mRNA) vaccine development have vastly enhanced their use as alternatives to conventional vaccines in the prevention of various infectious diseases and treatment of several types of cancers. This is mainly due to their remarkable ability to stimulate specific immune responses with minimal clinical side effects. This review gives a detailed overview of mRNA vaccines currently in use or at various stages of development, the recent advancements in mRNA vaccine development, and the challenges encountered in their development. Future perspectives on this technology are also discussed.

Keywords: COVID-19; cancer; mRNA vaccines.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

RNA, Messenger / genetics
Vaccine Development*

Substances

RNA, Messenger