Cryptogenic organic pneumonia (COP) refers to organic pneumonia that has not been identified a clear cause by current medical methods. A small proportion of COP can exhibit severe and progressive characteristics, while severe COP can cause systemic inflammatory storms and can be secondary to hemophilia. This article reported a case of acute severe COP secondary to hemophilia. A 67-year-old male patient was admitted to the hospital due to cough, shortness of breath, and fever. At first, he was misdiagnosed as severe pneumonia, but failed to receive anti infection treatments. Sputum pathogenetic examination and Macrogene testing of alveolar lavage fluid were performed, and no etiology was found to explain the patient's condition. The condition was gradually worsened and hemophilia occurred to explain, suggesting that acute severe COP was relevant. After receiving hormone treatment, the condition gradually relieved and the absorption of lung lesions improved. Hemophilia secondary to COP is rare, and the specific mechanism needs further study.
隐源性机化性肺炎(cryptogenic organic pneumonia，COP)是指目前医疗手段未发现明确致病原因的机化性肺炎，有少部分COP可呈重症急进型特征，此类COP引起全身炎症风暴，可继发嗜血现象。现报告1例重症急进型COP继发嗜血现象病例，该患者为67岁男性，因咳嗽、气促、发热入院，起初误诊为重症肺炎，经抗感染治疗无效，且多次痰液病原学检查、肺泡灌洗液宏基因检测，未发现能解释患者病情的原因。患者病情逐渐恶化，出现嗜血现象，生化指标紊乱，考虑重症急进型COP，遂予激素治疗，病情逐渐缓解，肺部病灶吸收好转。COP继发嗜血现象罕见，具体机制需进一步研究论证。.
Keywords: acute severe cryptogenic organizing pneumonia; cryptogenic organic pneumonia; hemophilia.