The application of an applied electrical potential to generate electrical fields and forces to enhance affinity biosensors

Daniel E Hagness; Ying Yang; Richard D Tilley; J Justin Gooding

doi:10.1016/j.bios.2023.115577

The application of an applied electrical potential to generate electrical fields and forces to enhance affinity biosensors

Biosens Bioelectron. 2023 Oct 15:238:115577. doi: 10.1016/j.bios.2023.115577. Epub 2023 Aug 7.

Authors

Daniel E Hagness¹, Ying Yang², Richard D Tilley³, J Justin Gooding⁴

Affiliations

¹ School of Chemistry, The University of New South Wales, Sydney, New South Wales, 2052, Australia.
² School of Chemistry, The University of New South Wales, Sydney, New South Wales, 2052, Australia; Australia Centre for Nanomedicine, The University of New South Wales, Sydney, New South Wales, 2052, Australia.
³ School of Chemistry, The University of New South Wales, Sydney, New South Wales, 2052, Australia; Electron Microscope Unit, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, New South Wales, 2052, Australia.
⁴ School of Chemistry, The University of New South Wales, Sydney, New South Wales, 2052, Australia; Australia Centre for Nanomedicine, The University of New South Wales, Sydney, New South Wales, 2052, Australia. Electronic address: justin.gooding@unsw.edu.au.

PMID: 37579531
DOI: 10.1016/j.bios.2023.115577

Abstract

Affinity biosensors play a crucial role in clinical diagnosis, pharmaceuticals, immunology, and other areas of human health. Affinity biosensors rely on the specific binding between target analytes and biological ligands such as antibodies, nucleic acids, aptamers, or other receptors to primarily generate electrochemical or optical signals. Considerable effort has been put into improving the performance of the affinity technologies to make them more sensitive, efficient and reproducible, of the many approaches electrokinetic phenomena are a viable option. In this perspective, studies that combine electrokinetic phenomena with affinity biosensor are discussed about their promise for achieving higher sensitivity and lower detection limit.

Keywords: Affinity biosensor; Dielectrophoresis; Electro-osmosis; Electrokinetic phenomena; Electrophoresis; Electrothermal effects.

Publication types

Review

MeSH terms

Antibodies
Aptamers, Nucleotide*
Biosensing Techniques*
Humans
Ligands
Nucleic Acids*

Substances

Nucleic Acids
Antibodies
Aptamers, Nucleotide
Ligands