Microbiota dysbiosis in hereditary angioedema patients

Öner Özdemir

doi:10.1016/j.waojou.2023.100806

Microbiota dysbiosis in hereditary angioedema patients

World Allergy Organ J. 2023 Aug 1;16(8):100806. doi: 10.1016/j.waojou.2023.100806. eCollection 2023 Aug.

Author

Öner Özdemir¹

Affiliation

¹ Division of Allergy and Immunology, Department of Pediatrics, Research and Training Hospital of Sakarya University Medical Faculty, Adapazarı, Sakarya, Türkiye.

Abstract

I have read the article titled "Throat microbiota alterations in patients with hereditary angioedema" by Wang et al (2022) with great interest. This study examined the change in throat microbiota and its association with laryngeal edema (LE) attacks and attack severity in hereditary angioedema (HAE) patients. This study demonstrated the comparative richness of Bacteroidetes and Prevotellaceae in recent LE attacks and detected positive association between the attack severity scores and Bacteroidetes richness. Nevertheless, I have some questions and concerns about the methodological design of their study. For instance, in the article, the description of HAE and HAE patients is not exactly correct. I do not also agree with the authors on the effect of long-term prophylactic danazol use in HAE patients of this study. It is very important when or how the swab was obtained after the LE attack. The last, not the least, point now is what the authors suggest to improve this dysbiosis in these HAE patients. The discussion to elaborate these points in the study could be helpful and enlightening for readers and future research in this area.