Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid

María Paz Beyer; Luis A Videla; Camila Farías; Rodrigo Valenzuela

doi:10.3390/nu15153317

Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid

Nutrients. 2023 Jul 26;15(15):3317. doi: 10.3390/nu15153317.

Authors

María Paz Beyer¹, Luis A Videla², Camila Farías¹, Rodrigo Valenzuela¹

Affiliations

¹ Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380000, Chile.
² Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7810000, Chile.

Abstract

Docosahexaenoic acid (C22:6n-3, DHA) is the precursor of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families which have been considered therapeutic bioactive compounds for human health. Growing evidence indicates that DHA and SPMs are beneficial strategies in the amelioration, regulation, and duration of inflammatory processes through different biological actions. The present review discusses the reported therapeutic benefits of SPMs on various diseases and their potential clinical applications.

Keywords: anti-inflammation; docosahexaenoic acid; maresins; protectins; resolvins series D; specialized pro-resolving mediators.

Publication types

Review

MeSH terms

Docosahexaenoic Acids*
Eicosanoids*
Humans
Inflammation / drug therapy
Inflammation Mediators

Substances

Docosahexaenoic Acids
Eicosanoids
Inflammation Mediators

Grants and funding

This work was supported by Fondo Nacional de Desarrollo Científico y Tecnológico (National Fund for Scientific and Technological Research), FONDECYT Grant 1221098 (R.V.).