Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome

Molecules. 2023 Aug 4;28(15):5870. doi: 10.3390/molecules28155870.

Abstract

Bile acids are acknowledged as signaling molecules involved in metabolic syndrome. The Takeda G protein-coupled receptor 5 (TGR5) functions as a significant bile acid receptor. The accumulated evidence suggests that TGR5 involves lipid homeostasis, glucose metabolism, and inflammation regulation. In line with this, recent preclinical studies also demonstrate that TGR5 plays a significant role in the generation and progression of metabolic syndrome, encompassing type 2 diabetes mellitus, obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). In this review, we discuss the role of TGR5 in metabolic syndrome, illustrating the underlying mechanisms and therapeutic targets.

Keywords: TGR5; Takeda G protein-coupled receptor 5; bile acids; metabolic syndrome.

Publication types

  • Review

MeSH terms

  • Bile Acids and Salts
  • Diabetes Mellitus, Type 2* / metabolism
  • Humans
  • Metabolic Syndrome*
  • Non-alcoholic Fatty Liver Disease* / metabolism
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction

Substances

  • Receptors, G-Protein-Coupled
  • Bile Acids and Salts

Grants and funding

The study was funded by the National Nature Science Foundation of China (82260843, 82060649, 82160740); Zunyi City of China (ZSKHHZ [2021]290, QKHPTRC [2020]-16); and the Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile (QJJ [2022]048, QJJ [2022]006).