Generalized Polyspike Pattern in EEG Due to Aseptic Meningoencephalitis

Markus A Hobert; Justina Dargvainiene; Nils G Margraf

doi:10.3390/diagnostics13152569

Generalized Polyspike Pattern in EEG Due to Aseptic Meningoencephalitis

Diagnostics (Basel). 2023 Aug 2;13(15):2569. doi: 10.3390/diagnostics13152569.

Authors

Markus A Hobert¹, Justina Dargvainiene², Nils G Margraf¹

Affiliations

¹ Department of Neurology, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
² Institute of Clinical Chemistry, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.

Abstract

We report the electroencephalography (EEG) showing an intermittent generalized polyspike pattern in EEG due to an aseptic meningoencephalitis in a 71-year-old soporous patient. Initially, she presented with word-finding disturbances and later with generalized tonic-clonic seizures. The cerebrospinal fluid (CSF) showed pleocytosis of 99 leukocytes/μL (primarily neutrophils) and an increased protein level of 1240 mg/L (CSF/serum glucose ratio and lactate unremarkable). Pathogens and autoimmune antibodies in CSF were not found. Brain imaging was unremarkable. After antibiotic, antiviral and anticonvulsive therapy, the pattern in the EEG was no longer detectable. The patient was discharged to go home due to absence of any residues.

Keywords: aseptic meningoencephalitis; electroencephalogram; polyspike.

Grants and funding

This research received no external funding.