Mechanistic role of CXCL5 in cardiovascular disease, diabetes mellitus, and kidney disease

Ching Chen; Ting-Ting Chang; Jaw-Wen Chen

doi:10.1016/j.lfs.2023.122018

Mechanistic role of CXCL5 in cardiovascular disease, diabetes mellitus, and kidney disease

Life Sci. 2023 Oct 1:330:122018. doi: 10.1016/j.lfs.2023.122018. Epub 2023 Aug 9.

Authors

Ching Chen¹, Ting-Ting Chang², Jaw-Wen Chen³

Affiliations

¹ Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
² Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: tf0619@nycu.edu.tw.
³ Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Cardiology, Department of Medicine and Department of Research, Taipei Medical University Hospital, Taipei, Taiwan; Cardiovascular Research Center, Taipei Medical University Hospital and Taipei Medical University, Taipei, Taiwan; Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: iwchen99@gmail.com.

PMID: 37567498
DOI: 10.1016/j.lfs.2023.122018

Abstract

Chemokines, by modulating inflammation process, could contribute to the development of cardiovascular disease, diabetes mellitus (DM), and kidney disease. Chemokine CXC motif ligand 5 (CXCL5) is one of the inducible chemokines that may be involved in various inflammatory diseases. Given the bidirectional promiscuity characteristics of the chemokine system, the mechanistic roles of CXCL5 should be further explored in each specific disease. In this article, we sought to review the recent evidence on the differential effects of CXCL5 and their potential mechanisms in cardiovascular disease, DM, and renal disease individually. Future study is still required to verify if CXCL5 could be a novel therapeutic target in these diseases.

Keywords: CXCL5; Cardiovascular disease; Chemokine; Diabetes mellitus; Kidney disease.

Publication types

Review

MeSH terms

Cardiovascular Diseases*
Chemokine CXCL5
Chemokines
Diabetes Mellitus*
Humans
Kidney Diseases*

Substances

Chemokines
CXCL5 protein, human
Chemokine CXCL5