Symptom Clusters in Adults with Post-COVID-19: A Cross-Sectional Survey

Clin Nurs Res. 2023 Nov;32(8):1071-1080. doi: 10.1177/10547738231191655. Epub 2023 Aug 11.

Abstract

More than 100 symptoms have been reported for post-coronavirus disease 2019 (COVID-19) and this study aimed to organize self-reported symptoms by identifying symptom clusters. We used a cross-sectional survey with a convenience sample of 491 adults who reported experiencing prolonged symptoms of COVID. A list of 25 symptoms of post-COVID-19 was used to measure the symptoms, and exploratory factor analysis was undertaken to identify symptom clusters for people with symptoms lasting 5 to 8 weeks and 9 weeks or longer. Six symptom clusters were identified for each of the two groups, and five clusters were similar across both groups: respiratory, general viral, smell/taste, cognitive cardiac, and mental health. The >9-week group reported symptoms primarily from two factors: respiratory-muscular and mental health. Post-COVID-19 symptom clusters differ across timeframes. Symptom clusters were useful in establishing coherent patterns of multiple complex symptoms.

Keywords: COVID-19; long COVID; post-COVID condition; symptom cluster.

MeSH terms

  • Adult
  • COVID-19*
  • Cross-Sectional Studies
  • Humans
  • Mental Health
  • Syndrome