Relation between Biochemical Parameters and Bone Density in Postmenopausal Women with Osteoporosis

Mohammad Reza Salamat; Shokouh Momeni; Ali Asghar Rastegari

doi:10.4103/abr.abr_135_22

Relation between Biochemical Parameters and Bone Density in Postmenopausal Women with Osteoporosis

Adv Biomed Res. 2023 Jun 30:12:162. doi: 10.4103/abr.abr_135_22. eCollection 2023.

Authors

Mohammad Reza Salamat¹, Shokouh Momeni², Ali Asghar Rastegari²

Affiliations

¹ Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
² Department of Molecular and Cell Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.

Abstract

Background: Osteoporosis is the most prevalent metabolic bone disease in postmenopausal women associated with reduced bone mass and increased bone fracture. Measuring bone density in the lumbar spine and hip is a reliable measure of bone mass and can therefore specify the risk of fracture. Dual-energy X-ray absorptiometry (DXA) is an accurate non-invasive system measuring bone density, with a low margin of error and no complications. The present study aimed to investigate the relationship between biochemical parameters with bone density in postmenopausal women.

Materials and methods: This cross-sectional study was conducted on 87 postmenopausal women referred to osteoporosis centers in Isfahan. Bone density was measured in the spine and hip area using the DXA system. Serum levels of calcium, phosphorus, alkaline phosphatase, and magnesium were measured by an autoanalyzer, and serum levels of vitamin D were measured by high-performance liquid chromatography (HPLC).

Results: The mean parameters of calcium, phosphorus, alkaline phosphatase, vitamin D, and magnesium did not show a significant difference between the two groups (P-value > 0.05). In the control group, the relationship between alkaline phosphatase and bone mineral content (BMC) and bony area (BA) in the spine was significant with a correlation coefficient of - 0.402 and 0.258, respectively (P-value < 0.05) and BMD and T-score in the femoral neck area showed a direct and significant relationship with phosphorus (correlation = 0.368; P value = 0.038). There was a significant relationship between the Z-score with calcium (correlation = 0.358; P value = 0.044).

Conclusion: There was no significant relationship between the values of calcium, phosphorus, alkaline phosphatase, vitamin D, and magnesium parameters and bone density (spine and hip) in postmenopausal women with osteopenia or osteoporosis.

Keywords: Alkaline phosphatase; bone mineral density; calcium; magnesium; menopause; osteoporosis; phosphorus; vitamin D.