Current status and perspectives in the surgical and oncological management of intrahepatic cholangiocarcinoma

Alix Dhote; Stylianos Tzedakis; Ortal Itzaki Shapira; Alexandra Nassar; Karim Boudjema; David Fuks

doi:10.1016/j.jviscsurg.2023.07.007

Current status and perspectives in the surgical and oncological management of intrahepatic cholangiocarcinoma

J Visc Surg. 2023 Oct;160(5):346-355. doi: 10.1016/j.jviscsurg.2023.07.007. Epub 2023 Aug 8.

Authors

Alix Dhote¹, Stylianos Tzedakis², Ortal Itzaki Shapira³, Alexandra Nassar², Karim Boudjema⁴, David Fuks⁵

Affiliations

¹ AP-HP, Cochin Port Royal Hospital Group, DMU Cancerology and medical-surgical specialties, Digestive, Hepatobiliary and Endocrine Surgery Department, Paris, France; Paris-Sorbonne University, Paris, France.
² AP-HP, Cochin Port Royal Hospital Group, DMU Cancerology and medical-surgical specialties, Digestive, Hepatobiliary and Endocrine Surgery Department, Paris, France; Paris Cité University, Paris, France.
³ AP-HP, Cochin Port Royal Hospital Group, DMU Cancerology and medical-surgical specialties, Digestive, Hepatobiliary and Endocrine Surgery Department, Paris, France.
⁴ Hepatobiliary and Digestive Surgery Department, Pontchaillou Hospital, Rennes 1 University, Rennes, France.
⁵ AP-HP, Cochin Port Royal Hospital Group, DMU Cancerology and medical-surgical specialties, Digestive, Hepatobiliary and Endocrine Surgery Department, Paris, France; Paris Cité University, Paris, France. Electronic address: david.fuks@aphp.fr.

PMID: 37563006
DOI: 10.1016/j.jviscsurg.2023.07.007

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor after hepatocellular carcinoma (HCC). Management depends on their resectability at the time of diagnosis. Two types can be distinguished by imaging: resectable ICCs amenable to surgery and locally advanced and/or metastatic ICCs, that are treated by chemotherapy, radiotherapy or loco-regional treatment (radioembolization, chemoembolization, intra-arterial chemotherapy and thermoablation). Over the last decade, the management strategy for these tumors has been modified by the appearance of loco-regional treatments as well as the introduction of immunotherapy that have shown their efficacy in the control of ICC. The aim of this review is to describe the current status of treatments for ICCs, as well as the different therapeutic strategies being assessed.

Keywords: Chemotherapy; Hepatectomy; Intrahepatic cholangiocarcinoma; Radio-embolization; immunotherapy; neoadjuvant treatment.

Publication types

Review

MeSH terms

Bile Duct Neoplasms* / surgery
Bile Ducts, Intrahepatic / pathology
Carcinoma, Hepatocellular* / surgery
Cholangiocarcinoma* / surgery
Hepatectomy
Humans
Liver Neoplasms* / pathology
Liver Neoplasms* / surgery