Resident dendritic cell density in the lymph node paracortex is preDC-estined

Rafael S Czepielewski; Gwendalyn J Randolph

doi:10.1016/j.immuni.2023.07.013

Resident dendritic cell density in the lymph node paracortex is preDC-estined

Immunity. 2023 Aug 8;56(8):1699-1701. doi: 10.1016/j.immuni.2023.07.013.

Authors

Rafael S Czepielewski¹, Gwendalyn J Randolph²

Affiliations

¹ Immunology Center of Georgia, Medical College of Georgia, Department of Physiology, Augusta University, Augusta, GA, USA.
² Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: gjrandolph@wustl.edu.

PMID: 37557075
DOI: 10.1016/j.immuni.2023.07.013

Abstract

Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

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MeSH terms

Dendritic Cells
Lymph Nodes*
Lymphoid Tissue*