Nanoparticles modulate heavy-metal and arsenic stress in food crops: Hormesis for food security/safety and public health

Abstract

Heavy metal and arsenic (HM-As) contamination at the soil-food crop interface is a threat to food security/safety and public health worldwide. The potential ecotoxicological effects of HM-As on food crops can perturb normal physiological, biochemical, and molecular processes. To protect food safety and human health, nanoparticles (NPs) can be applied to seed priming and soil amendment, as 'manifestation of hormesis' to modulate HM-As-induced oxidative stress in edible crops. This review provides a comprehensive overview of NPs-mediated alleviation of HM-As stress in food crops and resulting hormetic effects. The underlying biochemical and molecular mechanisms in the amelioration of HM-As-induced oxidative stress is delineated by covering the various aspects of the interaction of NPs (e.g., magnetic particles, silicon, metal oxides, selenium, and carbon nanotubes) with plant microbes, phytohormone, signaling molecules, and plant-growth bioregulators (e.g., salicylic acid and melatonin). With biotechnical advances (such as clustered regularly interspaced short palindromic repeats (CRISPR) gene editing and omics), the efficacy of NPs and associated hormesis has been augmented to produce "pollution-safe designer cultivars" in HM-As-stressed agriculture systems. Future research into nanoscale technological innovations should thus be directed toward achieving food security, sustainable development goals, and human well-being, with the aid of HM-As stress resilient food crops.

Keywords: Arsenic; Cadmium; Food crops; Hormesis; Nanoscale particles; Oxidative stress; Public health; Sustainable development goals.