Improved source localization in passive acoustic mapping using delay-multiply-and-sum beamforming with virtually augmented aperture

Che-Chou Shen; You-An Chen; Hsin-Yu Ku

doi:10.1016/j.ultras.2023.107125

Improved source localization in passive acoustic mapping using delay-multiply-and-sum beamforming with virtually augmented aperture

Ultrasonics. 2023 Dec:135:107125. doi: 10.1016/j.ultras.2023.107125. Epub 2023 Jul 27.

Authors

Che-Chou Shen¹, You-An Chen², Hsin-Yu Ku²

Affiliations

¹ Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan. Electronic address: choushen@mail.ntust.edu.tw.
² Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.

PMID: 37542780
DOI: 10.1016/j.ultras.2023.107125

Abstract

High-intensity focused ultrasound (HIFU) is a promising non-invasive treatment method whose applications include tissue ablation, hemostasis, thrombolysis and blood-brain barrier opening etc. Its therapeutic effects come from the thermal necrosis and the mechanical destruction associated with acoustic cavitation. Passive acoustic mapping (PAM) is capable of simultaneous monitoring of HIFU-induced cavitation events using only receive beamforming. Nonetheless, conventional time exposure acoustics (TEA) algorithm has poor spatial resolution and suffers from the X-shaped artifacts. These factors lead to difficulties in precise localization of cavitation source. In this study, we proposed a novel adaptive PAM method which combines Delay-Multiply-and-Sum (DMAS) beamforming with virtual augmented aperture (VA) to overcome the problem. In DMAS-VA beamforming, the magnitude of each channel waveform is scaled by p-th root while the phase is multiplied by L. The p and L correspond respectively to the degree of signal coherence in DMAS beamforming and the augmentation factor of aperture size. After channel sum, p-th power is applied to restore the dimensionality of source strength and then the PAM image is reconstructed by accumulating the signal power over the observation time. Based on simulation and experimental results, the proposed DMAS-VA has better image resolution and image contrast compared with the conventional TEA. Moreover, since the VA method may introduce grating lobes into PAM because of the virtually augmented pitch size, DMAS coherent factor (DCF) is further developed to alleviate these image artifacts. Results indicate that, with DCF weighting, the PAM image of DMAS-VA beamforming could be constructed without detectable image artifacts from grating lobes and false main lobes.

Keywords: DMAS coherent factor (DCF); Delay-multiply and sum (DMAS); High-intensity focused ultrasound (HIFU); Passive acoustic mapping (PAM); Virtually augmented aperture.