Organic photoredox-catalyzed oxidative azolation of unactivated fluoroarenes

Guodong Ju; Yalong Li; Yingsheng Zhao

doi:10.1039/d3ob01041d

Organic photoredox-catalyzed oxidative azolation of unactivated fluoroarenes

Org Biomol Chem. 2023 Aug 16;21(32):6503-6508. doi: 10.1039/d3ob01041d.

Authors

Guodong Ju¹, Yalong Li¹, Yingsheng Zhao^{1

2}

Affiliations

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science Soochow University, Suzhou 215123, PR China. yszhao@suda.edu.cn.
² School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, P. R. China.

PMID: 37540014
DOI: 10.1039/d3ob01041d

Abstract

Inexpensive and commercially available 2,4,6-triphenylpyrrolium tetrafluoroborate (TPT) is used as an organic photocatalyst for the nucleophilic aromatic substitution of unactivated fluoroarenes with pyrazole derivatives (S_NAr) to form azole arenes. The use of organic photoredox catalysis enables the easy operation of this method under mild conditions. Various fluorinated aromatic compounds are suitable electrophiles for this transformation.