Survival prediction of hepatocellular carcinoma by measuring the extracellular volume fraction with single-phase contrast-enhanced dual-energy CT imaging

Yan Chen; Kexin Shi; Zhen Li; Huixia Wang; Nana Liu; Pengchao Zhan; Xing Liu; Bo Shang; Ping Hou; Jianbo Gao; Peijie Lyu

doi:10.3389/fonc.2023.1199426

Survival prediction of hepatocellular carcinoma by measuring the extracellular volume fraction with single-phase contrast-enhanced dual-energy CT imaging

Front Oncol. 2023 Jul 19:13:1199426. doi: 10.3389/fonc.2023.1199426. eCollection 2023.

Authors

Yan Chen¹, Kexin Shi², Zhen Li³, Huixia Wang¹, Nana Liu¹, Pengchao Zhan¹, Xing Liu¹, Bo Shang¹, Ping Hou¹, Jianbo Gao¹, Peijie Lyu¹

Affiliations

¹ Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
² Department of Clinical Medicine, Henan Medical School of Zhengzhou University, Zhengzhou, Henan, China.
³ Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Abstract

Purpose: This study aimed to investigate the value of quantified extracellular volume fraction (fECV) derived from dual-energy CT (DECT) for predicting the survival outcomes of patients with hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).

Materials and methods: A total of 63 patients with HCC who underwent DECT before treatment were retrospectively included. Virtual monochromatic images (VMI) (70 keV) and iodine density images (IDI) during the equilibrium phase (EP) were generated. The tumor VMI-fECV and IDI-fECV were measured and calculated on the whole tumor (Whole) and maximum enhancement of the tumor (Maximum), respectively. Univariate and multivariate Cox models were used to evaluate the effects of clinical and imaging predictors on overall survival (OS) and progression-free survival (PFS).

Results: The correlation between tumor VMI-fECV and IDI-fECV was strong (both p< 0.001). The Bland-Altman plot between VMI-fECV and IDI-fECV showed a bias of 5.16% for the Whole and 6.89% for the Maximum modalities, respectively. Increasing tumor VMI-fECV and IDI-fECV were positively related to the effects on OS and PFS (both p< 0.05). The tumor IDI-fECV-Maximum was the only congruent independent predictor in patients with HCC after TACE in the multivariate analysis on OS (p = 0.000) and PFS (p = 0.028). Patients with higher IDI-fECV-Maximum values had better survival rates above the optimal cutoff values, which were 35.42% for OS and 29.37% for PFS.

Conclusion: The quantified fECV determined by the equilibrium-phase contrast-enhanced DECT can potentially predict the survival outcomes of patients with HCC following TACE treatment.

Keywords: dual-energy; extracellular volume; hepatocellular carcinoma; multidetector computed tomography; prognosis factors.

Grants and funding

This study was supported by the Key Scientific Research Project of Higher Education in Henan Province (No. 22A320057) and the Key Research and Development and Promotion of Special (scientific and technical research) Projects in Henan Province (No. 232102311087).