Clinicopathological study on camel mastitis at Matrouh Governorate

Asmaa Abdallah Darwish

doi:10.5455/javar.2023.j680

Clinicopathological study on camel mastitis at Matrouh Governorate

J Adv Vet Anim Res. 2023 Jun 30;10(2):284-291. doi: 10.5455/javar.2023.j680. eCollection 2023 Jun.

Author

Asmaa Abdallah Darwish¹

Affiliation

¹ Animal and Poultry Health Department, Animal and Poultry Health Division, Desert Research Center, Cairo, Egypt.

Abstract

Objective: Camel mastitis is indeed a serious problem that can have significant impacts on animal health and production as well as pose a potential public health hazard. This work aimed to identify the bacterial species responsible for camel mastitis and evaluate the associated immunological and clinicopathological alterations in infected camels.

Materials and methods: Raw milk and blood samples were collected from 40 apparently healthy she-camels, and 40 she-camels suffered from clinical mastitis (CMG). Milk samples were subjected to bacteriological examination. Serum immunological, biochemical, and hematological parameters were estimated and statistically analyzed.

Results: Similar bacterial species were obtained from the two groups with different isolation rates.Staphylococcus epidermidis and Escherichia coliwere the dominant species in the apparently healthy group, whilePseudomonas aeruginosaandBacillus cereus were the dominant species in CMG. A significant (p < 0.05) elevation of the pro-inflammatory cytokines, acute phase proteins (APPs), free radicals, total protein, Glob, kidney and liver function tests, and triglyceride concentrations were detected in CMG, and a significant (p < 0.05) decrease in the anti-inflammatory cytokine, antioxidants, Alb, glucose, and T/LDL/HDL-cholesterol concentrations was observed in CMG. Microcytic hypochromic anemia with hypoferremia, hypotransferrinemia, hyperferritinemia, and neutrophilic leukocytosis was depicted in CMG. The estimated pro-inflammatory cytokines, APPs, and total antioxidant capacity (TAC) yielded high sensitivity and specificity, but the highest likelihood ratio was for TAC, fibrinogen (Fb), and ferritin, and the highest percentages of increase were for IL-1α and IL-1β.

Conclusion: The study emphasizes the importance of hygienic preventive measures to control camel mastitis and the importance of supportive treatment to reverse the hemato-biochemicaland iron profile changes that result from the immune response in mastitic she-camels. TAC, Fb, ferritin, IL-1α, and IL-1β are good biomarkers for camel mastitis.

Keywords: Bacterial causes; biomarkers; camel mastitis; clinicopathological alterations; immunological alterations; iron profile.