The Many Hosts of Mycobacteria 9 (MHM9): A conference report

Abigail Marie Klever; Kathleen A Alexander; Deepak Almeida; Matthew Z Anderson; Ray L Ball; Gillian Beamer; Paola Boggiatto; Jane E Buikstra; Bruce Chandler; Tiffany A Claeys; Aislinn E Concha; Paul J Converse; Keith M Derbyshire; Karen M Dobos; Kathryn M Dupnik; Janice J Endsley; Mark A Endsley; Kevin Fennelly; Carlos Franco-Paredes; Deanna A Hagge; Luanne Hall-Stoodley; Don Hayes Jr; Katherine Hirschfeld; Courtney A Hofman; Jennifer R Honda; Natalie M Hull; Igor Kramnik; Karen Lacourciere; Ramanuj Lahiri; Elise A Lamont; Michelle H Larsen; Timothy Lemaire; Sandrine Lesellier; Naomi R Lee; Christopher A Lowry; Najmus S Mahfooz; Temet M McMichael; Marlena R Merling; Michele A Miller; Jyothi F Nagajyothi; Elizabeth Nelson; Eric L Nuermberger; Maria T Pena; Claudia Perea; Brendan K Podell; Charlie J Pyle; Fred D Quinn; Murugesan V S Rajaram; Oscar Rosas Mejia; Michelle Rothoff; Saydie A Sago; Liliana C M Salvador; Andrew W Simonson; John S Spencer; Srinand Sreevatsan; Selvakumar Subbian; James Sunstrum; David M Tobin; K K Vidya Vijayan; Caelan T O Wright; Richard T Robinson

doi:10.1016/j.tube.2023.102377

The Many Hosts of Mycobacteria 9 (MHM9): A conference report

Tuberculosis (Edinb). 2023 Sep:142:102377. doi: 10.1016/j.tube.2023.102377. Epub 2023 Jul 23.

Authors

Abigail Marie Klever¹, Kathleen A Alexander², Deepak Almeida³, Matthew Z Anderson⁴, Ray L Ball⁵, Gillian Beamer⁶, Paola Boggiatto⁷, Jane E Buikstra⁸, Bruce Chandler⁹, Tiffany A Claeys¹, Aislinn E Concha¹⁰, Paul J Converse³, Keith M Derbyshire¹¹, Karen M Dobos¹², Kathryn M Dupnik¹³, Janice J Endsley¹⁴, Mark A Endsley¹⁴, Kevin Fennelly¹⁵, Carlos Franco-Paredes¹⁶, Deanna A Hagge¹⁷, Luanne Hall-Stoodley¹, Don Hayes Jr¹⁸, Katherine Hirschfeld¹⁹, Courtney A Hofman²⁰, Jennifer R Honda²¹, Natalie M Hull²², Igor Kramnik²³, Karen Lacourciere²⁴, Ramanuj Lahiri²⁵, Elise A Lamont²⁶, Michelle H Larsen²⁷, Timothy Lemaire²⁸, Sandrine Lesellier²⁹, Naomi R Lee³⁰, Christopher A Lowry¹⁰, Najmus S Mahfooz¹, Temet M McMichael¹, Marlena R Merling¹, Michele A Miller³¹, Jyothi F Nagajyothi³², Elizabeth Nelson³³, Eric L Nuermberger³, Maria T Pena²⁵, Claudia Perea³⁴, Brendan K Podell¹², Charlie J Pyle³⁵, Fred D Quinn³⁶, Murugesan V S Rajaram¹, Oscar Rosas Mejia¹, Michelle Rothoff⁹, Saydie A Sago¹⁰, Liliana C M Salvador³⁷, Andrew W Simonson³⁸, John S Spencer¹², Srinand Sreevatsan³⁹, Selvakumar Subbian⁴⁰, James Sunstrum⁴¹, David M Tobin³⁵, K K Vidya Vijayan⁴², Caelan T O Wright⁴³, Richard T Robinson⁴⁴

Affiliations

¹ Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA.
² Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, VA, USA; CARACAL/Chobe Research Institute Kasane, Botswana.
³ Center for Tuberculosis Research, Johns Hopkins University, Baltimore, MD, USA.
⁴ Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA; Department of Microbiology, The Ohio State University, Columbus, OH, USA.
⁵ Eckerd College, St. Petersburg, FL, USA.
⁶ Host Pathogen Interactions and Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
⁷ Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA.
⁸ Center for Bioarchaeological Research, Arizona State University, Tempe, AZ, USA.
⁹ Division of Public Health, Alaska Department of Health, AK, USA.
¹⁰ Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
¹¹ Division of Genetics, The Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Biomedical Sciences, University at Albany, Albany, NY, USA.
¹² Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA.
¹³ Center for Global Health, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
¹⁴ Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
¹⁵ Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD, USA.
¹⁶ Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO, USA; Hospital Infantil de México Federico Gómez, México, USA.
¹⁷ The Leprosy Mission International, Kathmandu, Nepal.
¹⁸ Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
¹⁹ Department of Anthropology, University of Oklahoma, Norman, OK, USA.
²⁰ Department of Anthropology, University of Oklahoma, Norman, OK, USA; Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK, USA.
²¹ Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA.
²² Department of Civil, Environmental, and Geodetic Engineering, The Ohio State University, Columbus, OH, USA.
²³ Pulmonary Center, The Department of Medicine, Boston University Chobanian & Aveedisian School of Medicine, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.
²⁴ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
²⁵ United States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA, USA.
²⁶ Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
²⁷ Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
²⁸ Norton Sound Health Corporation, Nome, AK, USA.
²⁹ French Agency for Food, Environmental & Occupational Health & Safety (ANSES), Laboratory for Rabies and Wildlife,Nancy, France.
³⁰ Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ, USA.
³¹ DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
³² Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
³³ Microbial Paleogenomics Unit, Dept of Genomes and Genetics, Institut Pasteur, Paris, France.
³⁴ Animal & Plant Health Inspection Service, United States Department of Agriculture, Ames, IA, USA.
³⁵ Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC, USA; Department of Immunology, Duke University School of Medicine, Durham, NC, USA.
³⁶ Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
³⁷ School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, USA.
³⁸ Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
³⁹ Pathobiology & Diagnostic Investigation Department, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
⁴⁰ Public Health Research Institute (PHRI), New Jersey Medical School, Rutgers University, Newark, NJ, USA.
⁴¹ Corewell East Health, Westland, MI, USA.
⁴² Department of Microbiology and Immunology, Center for AIDS Research, and Children's Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴³ Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
⁴⁴ Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Infectious Diseases Institute, The Ohio State University, OH, USA. Electronic address: richard.robinson@osumc.edu.

PMID: 37531864
PMCID: PMC10529179 (available on 2024-09-01)
DOI: 10.1016/j.tube.2023.102377

Abstract

The Many Hosts of Mycobacteria (MHM) meeting series brings together basic scientists, clinicians and veterinarians to promote robust discussion and dissemination of recent advances in our knowledge of numerous mycobacterial diseases, including human and bovine tuberculosis (TB), nontuberculous mycobacteria (NTM) infection, Hansen's disease (leprosy), Buruli ulcer and Johne's disease. The 9th MHM conference (MHM9) was held in July 2022 at The Ohio State University (OSU) and centered around the theme of "Confounders of Mycobacterial Disease." Confounders can and often do drive the transmission of mycobacterial diseases, as well as impact surveillance and treatment outcomes. Various confounders were presented and discussed at MHM9 including those that originate from the host (comorbidities and coinfections) as well as those arising from the environment (e.g., zoonotic exposures), economic inequality (e.g. healthcare disparities), stigma (a confounder of leprosy and TB for millennia), and historical neglect (a confounder in Native American Nations). This conference report summarizes select talks given at MHM9 highlighting recent research advances, as well as talks regarding the historic and ongoing impact of TB and other infectious diseases on Native American Nations, including those in Southwestern Alaska where the regional TB incidence rate is among the highest in the Western hemisphere.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Cattle
Coinfection*
Humans
Mycobacterium Infections, Nontuberculous* / microbiology
Mycobacterium tuberculosis*
Nontuberculous Mycobacteria
Tuberculosis, Bovine*

Abstract

Publication types

MeSH terms

Grants and funding