Nanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages

Yizhen Wang; Feibo Song; Siling Wang; Miaolin Lan; Tingdong Li; Huilin Guo; Yali Zhang; Shengxiang Ge; Zizheng Zheng; Ningshao Xia

doi:10.1038/s41392-023-01512-6

Nanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages

Signal Transduct Target Ther. 2023 Aug 2;8(1):284. doi: 10.1038/s41392-023-01512-6.

Authors

Yizhen Wang^#^{1

2}, Feibo Song^#^{1

2}, Siling Wang^#^{3

4}, Miaolin Lan^#^{1

2}, Tingdong Li^#^{1

2}, Huilin Guo^{1

2}, Yali Zhang^{1

2}, Shengxiang Ge^{5

6}, Zizheng Zheng^{7

8}, Ningshao Xia^{1

2

9}

Affiliations

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China.
² Xiang An Biomedicine Laboratory, Xiamen, China.
³ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China. silingwang@xmu.edu.cn.
⁴ Xiang An Biomedicine Laboratory, Xiamen, China. silingwang@xmu.edu.cn.
⁵ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China. sxge@xmu.edu.cn.
⁶ Xiang An Biomedicine Laboratory, Xiamen, China. sxge@xmu.edu.cn.
⁷ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China. zhengzizheng@xmu.edu.cn.
⁸ Xiang An Biomedicine Laboratory, Xiamen, China. zhengzizheng@xmu.edu.cn.
⁹ Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences, Xiamen, China.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Immunoglobulins*

Substances

Immunoglobulins