Invasive Carcinoma With Skin Adnexal Trichilemmal Hair Follicular Differentiation Occurring in the Breast: A Case Report With Detailed Immunohistochemical and Molecular Analysis

Int J Surg Pathol. 2024 Jun;32(4):796-802. doi: 10.1177/10668969231189166. Epub 2023 Jul 31.

Abstract

Cutaneous-type adnexal tumors involving the breast are rare and create a diagnostic dilemma as they are often indistinguishable from primary mammary neoplasms. Tumors showing hair follicular differentiation are particularly challenging due to their rarity and the subtle appreciation of the intricate microanatomy of the hair follicle. We report a triple negative cutaneous-type adnexal carcinoma with follicular differentiation involving the breast to bring attention to the existence of these specialized group of tumors which should be managed differently from conventional triple negative carcinomas of the breast.

Keywords: adnexal tumors; breast; cutaneous; follicular differentiation.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor* / analysis
  • Biomarkers, Tumor* / metabolism
  • Breast / pathology
  • Breast / surgery
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / pathology
  • Carcinoma, Skin Appendage / diagnosis
  • Carcinoma, Skin Appendage / pathology
  • Diagnosis, Differential
  • Female
  • Hair Follicle* / pathology
  • Humans
  • Immunohistochemistry*
  • Middle Aged
  • Neoplasms, Adnexal and Skin Appendage / diagnosis
  • Neoplasms, Adnexal and Skin Appendage / pathology
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / pathology
  • Triple Negative Breast Neoplasms / diagnosis
  • Triple Negative Breast Neoplasms / pathology

Substances

  • Biomarkers, Tumor