A Notorious Trio! Inflammation, Metabolic Syndrome and Vitiligo

Amany I Mustafa; Ahmed M Hamed; Ahmed S Kadah; Eman M Fawzy; Ola S El Shimi

doi:10.4103/idoj.idoj_674_22

A Notorious Trio! Inflammation, Metabolic Syndrome and Vitiligo

Indian Dermatol Online J. 2023 Jun 28;14(4):493-499. doi: 10.4103/idoj.idoj_674_22. eCollection 2023 Jul-Aug.

Authors

Amany I Mustafa¹, Ahmed M Hamed¹, Ahmed S Kadah², Eman M Fawzy³, Ola S El Shimi⁴

Affiliations

¹ Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Cairo, Egypt.
² Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
³ Department of Laboratory Medicine, Mansoura Fever Hospital, Mansoura, Egypt.
⁴ Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Cairo, Egypt.

Abstract

Background: There is evidence to support that vitiligo is linked to metabolic syndrome (MS), confirming its systemic nature. However, the underlying pathogenic mechanisms remain unknown.

Objectives: To reveal the possible association of MS with vitiligo. We also attempted to study the connection between some inflammatory markers and MS in vitiligo patients to evaluate their utility in predicting MS risk.

Materials and methods: The study included 100 vitiligo patients with an age range between 18 to 60 years and 100 controls with matched age, gender, and body mass index. All subjects were tested for MS components. Serum visceral adipose tissue-derived serine protease inhibitor (vaspin), fatty acid binding protein 4 (FABP4), vascular adhesion protein 1 (VAP-1), chitinase-3-like protein 1 (YKL-40), and high-sensitivity C-reactive protein (hs-CRP) were also measured.

Results: Regarding MS, it was observed in 22.0% of vitiligo patients and 2.0% of control subjects (P < 0.001). Serum FABP4, VAP-1, YKL-40, and hs-CRP concentrations were higher in patients than in the control group (P < 0.05 each), and their levels showed high sensitivity and specificity to differentiate MS when using the receiver operating characteristic (ROC). Levels of these markers, except serum vaspin, were significantly positively correlated with lipid profile markers (except high-density lipoprotein cholesterol) and fasting blood glucose levels (P < 0.05 each).

Conclusion: MS was more common in vitiligo patients. The levels of the biomarkers studied were significantly higher in vitiligo patients. Furthermore, their levels accurately predicted MS in vitiligo patients. According to current research, these markers may be useful in assessing MS risk in vitiligo patients. Extensive research, however, is required.

Keywords: Inflammation; metabolic syndrome; vitiligo.