Insula neuroanatomical networks predict interoceptive awareness

Alan S R Fermin; Takafumi Sasaoka; Toru Maekawa; Hui-Ling Chan; Maro G Machizawa; Go Okada; Yasumasa Okamoto; Shigeto Yamawaki

doi:10.1016/j.heliyon.2023.e18307

Insula neuroanatomical networks predict interoceptive awareness

Heliyon. 2023 Jul 18;9(8):e18307. doi: 10.1016/j.heliyon.2023.e18307. eCollection 2023 Aug.

Authors

Alan S R Fermin¹, Takafumi Sasaoka¹, Toru Maekawa¹, Hui-Ling Chan¹, Maro G Machizawa¹, Go Okada², Yasumasa Okamoto², Shigeto Yamawaki¹

Affiliations

¹ Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 734-8553, Hiroshima city, Hiroshima, Japan.
² Department of Psychiatry and Neurosciences, Hiroshima University, 734-8553, Hiroshima city, Hiroshima, Japan.

Abstract

Interoceptive awareness (IA), the subjective and conscious perception of visceral and physiological signals from the body, has been associated with functions of cortical and subcortical neural systems involved in emotion control, mood and anxiety disorders. We recently hypothesized that IA and its contributions to mental health are realized by a brain interoception network (BIN) linking brain regions that receive ascending interoceptive information from the brainstem, such as the amygdala, insula and anterior cingulate cortex (ACC). However, little evidence exists to support this hypothesis. In order to test this hypothesis, we used a publicly available dataset that contained both anatomical neuroimaging data and an objective measure of IA assessed with a heartbeat detection task. Whole-brain Voxel-Based Morphometry (VBM) was used to investigate the association of IA with gray matter volume (GMV) and the structural covariance network (SCN) of the amygdala, insula and ACC. The relationship between IA and mental health was investigated with questionnaires that assessed depressive symptoms and anxiety. We found a positive correlation between IA and state anxiety, but not with depressive symptoms. In the VBM analysis, only the GMV of the left anterior insula showed a positive association with IA. A similar association was observed between the parcellated GMV of the left dorsal agranular insula, located in the anterior insula, and IA. The SCN linking the right dorsal agranular insula with the left dorsal agranular insula and left hyper-granular insula were positively correlated with IA. No association between GMV or SCN and depressive symptoms or anxiety were observed. These findings revealed a previously unknown association between IA, insula volume and intra-insula SCNs. These results may support development of non-invasive neuroimaging interventions, e.g., neurofeedback, seeking to improve IA and to prevent development of mental health problems, such anxiety disorders.

Keywords: Active inference; Brain interoception network; Insula; Interoception; Interoceptive awareness.