Emerging biomedical imaging-based companion diagnostics for precision medicine

Shiyi Liao; Mengjie Zhou; Youjuan Wang; Chang Lu; Baoli Yin; Ying Zhang; Huiyi Liu; Xia Yin; Guosheng Song

doi:10.1016/j.isci.2023.107277

Emerging biomedical imaging-based companion diagnostics for precision medicine

iScience. 2023 Jul 3;26(8):107277. doi: 10.1016/j.isci.2023.107277. eCollection 2023 Aug 18.

Authors

Shiyi Liao¹, Mengjie Zhou¹, Youjuan Wang¹, Chang Lu¹, Baoli Yin¹, Ying Zhang¹, Huiyi Liu¹, Xia Yin¹, Guosheng Song¹

Affiliation

¹ State Key Laboratory for Chemo, Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, China.

Abstract

The tumor heterogeneity, which leads to individual variations in tumor microenvironments, causes poor prognoses and limits therapeutic response. Emerging technology such as companion diagnostics (CDx) detects biomarkers and monitors therapeutic responses, allowing identification of patients who would benefit most from treatment. However, currently, most US Food and Drug Administration-approved CDx tests are designed to detect biomarkers in vitro and ex vivo, making it difficult to dynamically report variations of targets in vivo. Various medical imaging techniques offer dynamic measurement of tumor heterogeneity and treatment response, complementing CDx tests. Imaging-based companion diagnostics allow for patient stratification for targeted medicines and identification of patient populations benefiting from alternative therapeutic methods. This review summarizes recent developments in molecular imaging for predicting and assessing responses to cancer therapies, as well as the various biomarkers used in imaging-based CDx tests. We hope this review provides informative insights into imaging-based companion diagnostics and advances precision medicine.

Keywords: Biomedical engineering; Diagnostics.

Publication types

Review