Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose-volume histogram

Takahiro Aoyama; Hidetoshi Shimizu; Yutaro Koide; Tomoki Kitagawa; Hiroyuki Tachibana; Kojiro Suzuki; Takeshi Kodaira

doi:10.1016/j.phro.2023.100468

Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose-volume histogram

Phys Imaging Radiat Oncol. 2023 Jul 5:27:100468. doi: 10.1016/j.phro.2023.100468. eCollection 2023 Jul.

Authors

Takahiro Aoyama¹, Hidetoshi Shimizu¹, Yutaro Koide¹, Tomoki Kitagawa¹, Hiroyuki Tachibana¹, Kojiro Suzuki², Takeshi Kodaira¹

Affiliations

¹ Department of Radiation Oncology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-Ku, Nagoya, Aichi 464-8681, Japan.
² Department of Radiology, Aichi Medical University, 1-1 Yazako-karimata, Nagakute, Aichi 480-1195 Japan.

Abstract

We investigated the risk of secondary cancers in rectum and bladder for prostate cancer radiotherapy using a feasibility assessment tool. We calculated the risk of secondary cancer by generating a dose-volume histogram based on an ideal dose falloff function (f-value). This study found a smaller f-value was associated with a lower secondary cancer risk in the rectum but a higher risk in the bladder. The study suggests setting the f-value at 0-0.1 as the optimization goal for the rectum and 0.4 for the bladder is reasonable and feasible for reducing the risk of secondary cancer and other adverse events.

Keywords: Excess absolute risk; F-value; Full mathematical model; Prostate; Radiotherapy; Secondary cancer.