Mimosa pudica mucilage nanoparticles of losartan potassium: Characterization and pharmacodynamics evaluation

Shazia Akram Ghumman; Arshad Mahmood; Sobia Noreen; Huma Hameed; Rizwana Kausar; Maria Rana; Asma Aslam

doi:10.1016/j.jsps.2023.101695

Mimosa pudica mucilage nanoparticles of losartan potassium: Characterization and pharmacodynamics evaluation

Saudi Pharm J. 2023 Aug;31(8):101695. doi: 10.1016/j.jsps.2023.101695. Epub 2023 Jul 6.

Authors

Shazia Akram Ghumman¹, Arshad Mahmood^{2

3}, Sobia Noreen⁴, Huma Hameed⁵, Rizwana Kausar⁶, Maria Rana⁷, Asma Aslam¹

Affiliations

¹ College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
² College of Pharmacy, Al Ain University, Abu Dhabi Campus, Abu Dhabi, UAE.
³ AAU Health and Biomedical Research Centre (HBRC), Al Ain University, UAE.
⁴ Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
⁵ Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore 54000, Pakistan.
⁶ ILM College of Pharmaceutical Sciences, Sargodha 40100, Pakistan.
⁷ Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore Campus, Lahore 54000, Pakistan.

Abstract

The current research was to develop nanoparticles based on Mimosa pudica mucilage (MPM) that could encapsulate losartan potassium (LP). Nanoparticles (NPs) produced through ionic-gelation method; the polymerization of the mucilage carried out using calcium chloride as cross-linking agent. The MPMLP-NPs demonstrated vastly enhanced pharmaceutical characteristics, presented discrete surface with spherical shape of 198.4-264.6 nm with PDI ranging 0.326-0.461 and entrapment efficiency was in the range of 80.65 ± 0.82-90.79 ± 0.96%. FTIR and DSC indicated the stability of drug during the formulation of nanoparticles. An acute oral toxicity investigation found no significant alterations in behavior and histopathology criteria. The MPMLP-NPs formulation revealed the better rates and sustained effect as assessed with the commercial product. Moreover, low dose of MPMLP-NPs showed similar anti-hypertensive effect as assessed with the marketed tablet.

Keywords: Losartan potassium; Mimosa pudica mucilage; Nanoparticles; Sustained effect.