Methionine restriction and antitumor immunity

Trends Cancer. 2023 Sep;9(9):705-706. doi: 10.1016/j.trecan.2023.07.008. Epub 2023 Jul 28.

Abstract

Fang et al. recently reported in Cancer Cell that methionine restriction increases antitumor immunity by enhancing cyclic GMP-AMP synthase (cGAS) activity and promoting its dissociation from chromatin. This finding identifies a potential strategy to target cGAS demethylation in cancer therapy by altering methionine metabolism.

Keywords: antitumor immunity; cGAS methylation; methionine restriction.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Chromatin
  • DNA*
  • Humans
  • Methionine*
  • Nucleotidyltransferases / genetics
  • Nucleotidyltransferases / metabolism
  • Racemethionine

Substances

  • DNA
  • Methionine
  • Chromatin
  • Racemethionine
  • Nucleotidyltransferases