Synthesis and biological activities of bicyclic pyridines integrated steroid hybrid

Mohamed M Hammouda; Khaled M Elattar; Marwa M Rashed; Amany M A Osman

doi:10.1016/j.steroids.2023.109287

Synthesis and biological activities of bicyclic pyridines integrated steroid hybrid

Steroids. 2023 Nov:199:109287. doi: 10.1016/j.steroids.2023.109287. Epub 2023 Jul 28.

Authors

Mohamed M Hammouda¹, Khaled M Elattar², Marwa M Rashed³, Amany M A Osman⁴

Affiliations

¹ Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt. Electronic address: elmhammouda@mans.edu.eg.
² Unit of Genetic Engineering and Biotechnology, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt. Electronic address: khaledelattar2@yahoo.com.
³ Toxicology Department, Mansoura Hospital, Faculty of Medicine, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt. Electronic address: marwarashed@mans.edu.eg.
⁴ Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt. Electronic address: amanyosman812@gmail.com.

PMID: 37517592
DOI: 10.1016/j.steroids.2023.109287

Abstract

Reports on structural modification of heterosteroids through various reactions, and developed synthetic routes have considerably increased over the last decade. The present review encompasses the applicable approaches dealing with the utility of reactive moieties in various steroids for the synthesis of fused bicyclic pyridines, and binary bicyclic pyridines all over the years. The different sections include the synthesis of steroids-fused, and binary quinolines, pyridopyrimidines, imidazopyridines, spirocyclic imidazopyridines, pyrazolopyridines, thienopyridines, pyridinyl-thiazoles, and tetrazolopyridine hybrids, as well as, the diverse biological applications of these heterocyclic steroids. The researchers' interest was principally focused on investigating the flexibility of synthetic strategies for various derivatives of natural steroids and building proposals based on heterocyclic steroids for drug discovery, biological assessments, and synthetic applications.

Keywords: Binary bicyclic pyridines; Biological features; Fused bicyclic pyridines; Pyridosteroids; Reactions’ mechanisms; Synthetic approaches.

Publication types

Review