Decoding the role of miRNAs in multiple myeloma pathogenesis: A focus on signaling pathways

Amr Mohamed Yehia; Elsayed G E Elsakka; Ahmed I Abulsoud; Nourhan M Abdelmaksoud; Ahmed Elshafei; Samy Y Elkhawaga; Ahmed Ismail; Mahmoud Mohamed Mokhtar; Hesham A El-Mahdy; Maghawry Hegazy; Mohammed S Elballal; Osama A Mohammed; Hussein M El-Husseiny; Heba M Midan; Walaa A El-Dakroury; Moataz B Zewail; Sherif S Abdel Mageed; Yasser M Moustafa; Randa M Mostafa; Mohamed A Elkady; Ahmed S Doghish

doi:10.1016/j.prp.2023.154715

Decoding the role of miRNAs in multiple myeloma pathogenesis: A focus on signaling pathways

Pathol Res Pract. 2023 Aug:248:154715. doi: 10.1016/j.prp.2023.154715. Epub 2023 Jul 26.

Authors

Amr Mohamed Yehia¹, Elsayed G E Elsakka¹, Ahmed I Abulsoud², Nourhan M Abdelmaksoud³, Ahmed Elshafei¹, Samy Y Elkhawaga¹, Ahmed Ismail¹, Mahmoud Mohamed Mokhtar¹, Hesham A El-Mahdy⁴, Maghawry Hegazy¹, Mohammed S Elballal⁵, Osama A Mohammed⁶, Hussein M El-Husseiny⁷, Heba M Midan⁵, Walaa A El-Dakroury⁸, Moataz B Zewail⁸, Sherif S Abdel Mageed⁹, Yasser M Moustafa¹⁰, Randa M Mostafa¹¹, Mohamed A Elkady¹, Ahmed S Doghish¹²

Affiliations

¹ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
² Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
³ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
⁴ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: heshamabbas@azhar.edu.eg.
⁵ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁶ Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt; Department of Clinical Pharmacology, Faculty of Medicine, Bisha University, Bisha 61922, Saudi Arabia.
⁷ Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya 13736, Egypt; Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai Cho, Fuchu-shi, Tokyo 183-8509, Japan.
⁸ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁹ Department of Pharmacology & Toxicology, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
¹⁰ Department of Pharmacology & Toxicology, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
¹¹ College of Medicine, Benha University, Egypt.
¹² Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg.

PMID: 37517169
DOI: 10.1016/j.prp.2023.154715

Abstract

Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in regulating gene expression in MM. Several non-coding RNAs have been demonstrated to regulate MM pathogenesis signaling pathways. These pathways might regulate MM development, apoptosis, progression, and therapeutic outcomes. They are Wnt/β-catenin, PI3K/Akt/mTOR, P53 and KRAS. This review highlights the impending role of miRNAs in MM signaling and their relationship with MM therapeutic interventions.

Keywords: MiRNAs; Multiple myeloma (MM), therapeutic intervention, signaling pathways.

Publication types

Review