Thymic mimicry: The art of imitation

J Exp Med. 2023 Oct 2;220(10):e20231010. doi: 10.1084/jem.20231010. Epub 2023 Jul 27.

Abstract

Display of tissue self-antigens within the thymus is critical for the regulation of self-reactive T cells. In this issue of JEM, Michelson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230461) continue to advance our understanding of self-antigen representation by medullary thymic epithelial cells, identifying a new role for Hnf4γ in the regulation of thymic mimetic cells as well as their peripheral counterparts.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantigens
  • Epithelial Cells
  • Imitative Behavior*
  • Thymus Gland*

Substances

  • Autoantigens