Evolution and Reassortment of H6 Subtype Avian Influenza Viruses

Mingqin Lin; Qiu-Cheng Yao; Jing Liu; Miaotong Huo; Yan Zhou; Minyi Chen; Yuanguo Li; Yuwei Gao; Ye Ge

doi:10.3390/v15071547

Evolution and Reassortment of H6 Subtype Avian Influenza Viruses

Viruses. 2023 Jul 13;15(7):1547. doi: 10.3390/v15071547.

Authors

Mingqin Lin¹, Qiu-Cheng Yao¹, Jing Liu¹, Miaotong Huo¹, Yan Zhou¹, Minyi Chen¹, Yuanguo Li², Yuwei Gao², Ye Ge¹

Affiliations

¹ College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524088, China.
² Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun 130000, China.

Abstract

The H6 subtype of avian influenza virus (H6 AIV) is the most detected AIV subtype in poultry and wild birds. It causes economic losses to the poultry industry, and the most important, H6 AIV may have the ability to infect mammals, which is a great threat to public health security. In addition, the H6 subtype can serve as a precursor to providing internal genes for other highly pathogenic AIVs, posing a potential threat. H6 AIV currently face to the high positive detection rate and harmless nature of H6 AIV and because not highly effective H6 subtype vaccine available on the market. In this study, we focused on the prevalence of H6 AIV in poultry and wild birds, phylogenetic analysis, genetic variation characteristics, selection analysis, and prevention and control to provide relevant references for the scientific prevention and control of H6 AIV in future.

Keywords: H6 subtype; avian influenza virus; genetics and evolution; prevention and control; reassortment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Wild
Birds
Influenza A virus* / genetics
Influenza in Birds* / epidemiology
Mammals
Phylogeny
Poultry

Grants and funding

This work was supported by the project from Forestry administration of Guangdong Province (No. K23051), Key Laboratory of Fishery Pharmaceutics Creation, Ministry of Agriculture, China (B19136) and program for scientific research start-up funds of Guangdong Ocean university (No. 521202292). This study was also supported by Guangdong Science and Technology Innovation Strategy Special Fund (College Student Science and Technology Innovation Cultivation) Project (pdjh2023b2049).