Progress in PRRSV Infection and Adaptive Immune Response Mechanisms

Huanchang Cai; Hewei Zhang; Huai Cheng; Min Liu; Shubo Wen; Jingqiang Ren

doi:10.3390/v15071442

Progress in PRRSV Infection and Adaptive Immune Response Mechanisms

Viruses. 2023 Jun 27;15(7):1442. doi: 10.3390/v15071442.

Authors

Huanchang Cai¹, Hewei Zhang^{2

3}, Huai Cheng¹, Min Liu¹, Shubo Wen⁴, Jingqiang Ren^{1

3}

Affiliations

¹ Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou 325035, China.
² College of Food and Drugs, Luoyang Polytechnic, Luoyang 471099, China.
³ Animal Diseases and Public Health Engineering Research Center of Henan Province, Luoyang 471000, China.
⁴ Preventive Veterinary Laboratory, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.

Abstract

Since its discovery, Porcine reproductive and respiratory syndrome (PRRS) has had a huge impact on the farming industry. The virus that causes PRRS is Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), and because of its genetic diversity and the complexity of the immune response, the eradication of PRRS has been a challenge. To provide scientific references for PRRSV control and vaccine development, this study describes the processes of PRRSV-induced infection and escape, as well as the host adaptive immune response to PRRSV. It also discusses the relationship between PRRSV and the adaptive immune response.

Keywords: PRRSV; adaptive immunity; non-neutralizing antibodies; persistent infection.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adaptive Immunity
Animals
Antibodies, Viral
Porcine Reproductive and Respiratory Syndrome*
Porcine respiratory and reproductive syndrome virus*
Swine
Viral Vaccines*

Substances

Viral Vaccines
Antibodies, Viral

Grants and funding

This research was funded by the Youth Growth Technology Project of Jilin Provincial Science and Technology Development Program (No. 20210508019RQ) and the Core Technical Public Welfare Project of Luoyang, China (No. 2202034A).