Polysaccharides from Passion Fruit Peels: From an Agroindustrial By-Product to a Viable Option for 5-FU-Induced Intestinal Damage

Karien Sauruk da Silva; Kahlile Youssef Abboud; Carolina Silva Schiebel; Natalia Mulinari Turin de Oliveira; Laryssa Regis Bueno; Lara Luisa Valerio de Mello Braga; Bruna Carla da Silveira; Isabella Wzorek França Dos Santos; Everton Dos Santos Gomes; Marcelo Biondaro Gois; Lucimara Mach Côrtes Cordeiro; Daniele Maria Ferreira

doi:10.3390/ph16070912

Polysaccharides from Passion Fruit Peels: From an Agroindustrial By-Product to a Viable Option for 5-FU-Induced Intestinal Damage

Pharmaceuticals (Basel). 2023 Jun 21;16(7):912. doi: 10.3390/ph16070912.

Authors

Karien Sauruk da Silva^{1

2}, Kahlile Youssef Abboud³, Carolina Silva Schiebel^{1

2}, Natalia Mulinari Turin de Oliveira^{1

2}, Laryssa Regis Bueno^{1

2}, Lara Luisa Valerio de Mello Braga^{1

2}, Bruna Carla da Silveira^{1

2}, Isabella Wzorek França Dos Santos^{1

2}, Everton Dos Santos Gomes^{4

5}, Marcelo Biondaro Gois^{4

5}, Lucimara Mach Côrtes Cordeiro³, Daniele Maria Ferreira^{1

2}

Affiliations

¹ Faculdades Pequeno Príncipe, Programa de Pós-graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Curitiba 80250-200, Brazil.
² Instituto de Pesquisa Pelé Pequeno Príncipe, Av. Silva Jardim No 1532, Curitiba 80250-200, Brazil.
³ Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba 81531-980, Brazil.
⁴ Programa de Pós-Graduação em Imunologia, Universidade Federal da Bahia, Salvador 40231-300, Brazil.
⁵ Programa de Pós-Graduação em Biociências e Saúde, Universidade Federal de Rondonópolis, Rondonópolis 78736-900, Brazil.

Abstract

Gastrointestinal mucositis is a serious and dose-limiting toxic side effect of oncologic treatment. Interruption of cancer treatment due to gastrointestinal mucositis leads to a significant decrease in cure rates and consequently to the deterioration of a patient's quality of life. Natural polysaccharides show a variety of beneficial effects, including a gastroprotective effect. Treatment with soluble dietary fiber (SDF) from yellow passion fruit (Passiflora edulis) biomass residues protected the gastric and intestinal mucosa in models of gastrointestinal injury. In this study, we investigated the protective therapeutic effect of SDF on 5-FU-induced mucositis in male and female mice. Oral treatment of the animals with SDF did not prevent weight loss but reduced the disease activity index and preserved normal intestinal function by alleviating diarrhea and altered gastrointestinal transit. SDF preserved the length of the colon and histological damage caused by 5-FU. SDF significantly restored the oxidative stress and inflammation in the intestine and the enlargement and swelling of the spleen induced by 5-FU. In conclusion, SDF may be a promising adjuvant strategy for the prevention and treatment of intestinal mucositis induced by 5-FU.

Keywords: 5-FU; Passiflora edulis; agroindustrial by-products; agroindustrial residues; chemotherapy damage; intestinal damage; intestinal injury.

Grants and funding

Thaís work was supported by the Instituto de Pesquisa Pelé Pequeno Príncipe (Brazil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq Grant numbers 404717/2016-0, 310332/2015-0, 307314/2018-9 to L.M.C.C.; and 302195/2022-0 to D.M.F.), and in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. The authors are master or doctoral students receiving a fellowship from CAPES, Fundação Araucária (Process 19–2015), or Instituto de Pesquisa Pelé Pequeno Príncipe.