Hemophagocytic Lymphohistiocytosis Secondary to Hodgkin's Lymphoma with Isolated Bone Marrow Involvement in a Newly Diagnosed HIV Patient

Medicina (Kaunas). 2023 Jul 9;59(7):1274. doi: 10.3390/medicina59071274.

Abstract

Human immunodeficiency virus (HIV) infection is known to be associated with the development of Hodgkin's lymphoma (HL). Exclusive extranodal bone marrow involvement is less common. Co-infection by other viruses, such as the Epstein-Barr virus (EBV), increases the incidence of a frequent complication denominated by hemophagocytic lymphohistocytosis (HLH). We present the case of a 50-year-old patient with the above clinical spectrum who develops several serious complications during treatment.

Keywords: Epstein–Barr virus; Hodgkin’s lymphoma; hemophagocytic lymphohistiocytosis; human immunodeficiency virus.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow / pathology
  • Epstein-Barr Virus Infections* / complications
  • HIV Infections* / complications
  • Herpesvirus 4, Human
  • Hodgkin Disease* / complications
  • Humans
  • Lymphohistiocytosis, Hemophagocytic* / complications
  • Lymphohistiocytosis, Hemophagocytic* / diagnosis
  • Middle Aged

Grants and funding

This research received no external funding.