Short Peptides of Innate Immunity Protein Tag7 (PGLYRP1) Selectively Induce Inhibition or Activation of Tumor Cell Death via TNF Receptor

Int J Mol Sci. 2023 Jul 12;24(14):11363. doi: 10.3390/ijms241411363.

Abstract

In this study, we have found two peptides of Tag7 (PGLYRP1) protein-17.1A (HRDVQRT) and 17.1B (RSNYVLKG), that have different affinities to the TNFR1 receptor and the Hsp70 protein. Peptide 17.1A is able to inhibit signal transduction through the TNFR1 receptor, and peptide 17.1B can activate this receptor in a complex with Hsp70. Thus, it is possible to modulate the activity of the TNFR1 receptor and further perform its specific inhibition or activation in the treatment of various autoimmune or oncological diseases.

Keywords: Hsp70; TNFR1; Tag7; cytotoxity; short peptides; signal transduction.

MeSH terms

  • Apoptosis
  • Cytokines* / metabolism
  • Humans
  • Immunity, Innate
  • Neoplasms*
  • Peptides / pharmacology
  • Receptors, Tumor Necrosis Factor, Type I* / genetics
  • Tumor Necrosis Factor-alpha

Substances

  • Cytokines
  • Peptides
  • PGLYRP1 protein, human
  • Receptors, Tumor Necrosis Factor, Type I
  • Tumor Necrosis Factor-alpha