Trace analysis of food by surface-enhanced Raman spectroscopy combined with molecular imprinting technology: Principle, application, challenges, and prospects

Jing Neng; Jiana Wang; Yan Wang; Yilong Zhang; Peng Chen

doi:10.1016/j.foodchem.2023.136883

Trace analysis of food by surface-enhanced Raman spectroscopy combined with molecular imprinting technology: Principle, application, challenges, and prospects

Food Chem. 2023 Dec 15:429:136883. doi: 10.1016/j.foodchem.2023.136883. Epub 2023 Jul 16.

Authors

Jing Neng¹, Jiana Wang², Yan Wang³, Yilong Zhang⁴, Peng Chen⁵

Affiliations

¹ College of Food Science and Engineering, Zhejiang University of Technology, Deqing 313299, China. Electronic address: nengjing@zjut.edu.cn.
² College of Food Science and Engineering, Zhejiang University of Technology, Deqing 313299, China. Electronic address: wangjiana@zjut.edu.cn.
³ College of Food Science and Engineering, Zhejiang University of Technology, Deqing 313299, China. Electronic address: wangyan062006@zjut.edu.cn.
⁴ College of Computer Science and Engineering, Zhejiang University of Technology, Hangzhou 310027, China. Electronic address: zhangyilong@zjut.edu.cn.
⁵ College of Computer Science and Engineering, Zhejiang University of Technology, Hangzhou 310027, China. Electronic address: chenpeng@zjut.edu.cn.

PMID: 37506657
DOI: 10.1016/j.foodchem.2023.136883

Abstract

Surface-enhanced Raman spectroscopy (SERS) is a rapid detection method with high sensitivity and simple pretreatment, but can be affected by interference from matrix components. By incorporating molecularly imprinted polymers (MIPs) that recognize specific targets, MIP-SERS sensors effectively overcome the interference of complex matrices and offer improved stability and sensitivity. This review provides a comprehensive understanding of the applications of MIP-SERS sensors for the detection of trace toxic substances in food. The underlying mechanism and development of SERS technology and the principle and classification of MIPs technology are discussed. Furthermore, the types of MIP-SERS sensors are introduced, with their advantages and disadvantages systematically illustrated. Recent advances in MIP-SERS technology for the detection of mycotoxins, additives, prohibited dyes, pesticides, veterinary drug residues, and other hazardous substances in food are highlighted. Finally, this review discusses the challenges associated with MIP-SERS technology and proposes future development prospects.

Keywords: Detection; Food; Molecularly imprinted polymers; Sensors; Surface-enhanced Raman spectroscopy.

Publication types

Review

MeSH terms

Molecular Imprinting* / methods
Molecularly Imprinted Polymers
Mycotoxins*
Pesticides*
Spectrum Analysis, Raman / methods

Substances

Molecularly Imprinted Polymers
Mycotoxins
Pesticides