Advances in Chemical Probing Concepts for Chemical Biology Applications

Paola B Arimondo; Sebastian Essig; Ulrich Schopfer; Arne Rufer

doi:10.1002/cbic.202300319

Advances in Chemical Probing Concepts for Chemical Biology Applications

Chembiochem. 2023 Sep 1;24(17):e202300319. doi: 10.1002/cbic.202300319. Epub 2023 Jul 27.

Authors

Paola B Arimondo¹, Sebastian Essig², Ulrich Schopfer³, Arne Rufer⁴

Affiliations

¹ Institut Pasteur, Université Paris Cité, CNRS UMR n° 3523 Chem4Life, Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, 75015, Paris, France.
² Bayer AG, Research & Development, Pharmaceuticals, Drug Discovery Sciences, Life Science Technologies, Aprather Weg 18a, Gebäude 460, Raum 345, 42113, Wuppertal, Germany.
³ Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Novartis Campus, 4056, Basel, Switzerland.
⁴ Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 065/208 A, 4070, Basel, Switzerland.

PMID: 37501334
DOI: 10.1002/cbic.202300319

Abstract

Chemical probes allow us to identify, validate and confirm novel targets for therapeutic applications, enable the development of drug candidates, and open the way to new therapeutic strategies, vaccines and diagnostic tools.

Keywords: chemical biology; chemical tools; detection; mechanisms of action; novel targets; omics technologies.

Publication types

Editorial

MeSH terms

Biology
Chemical Phenomena
Vaccines*

Substances

Vaccines