Sex differences in cardiometabolic biomarkers during the pre-diabetes stage

Yilin Yoshida; Zhipeng Chen; Vivian A Fonseca; Franck Mauvais-Jarvis

doi:10.1016/j.diabres.2023.110856

Sex differences in cardiometabolic biomarkers during the pre-diabetes stage

Diabetes Res Clin Pract. 2023 Sep:203:110856. doi: 10.1016/j.diabres.2023.110856. Epub 2023 Jul 26.

Authors

Yilin Yoshida¹, Zhipeng Chen², Vivian A Fonseca³, Franck Mauvais-Jarvis³

Affiliations

¹ Section of Endocrinology and Metabolism, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address: yyoshida1@tulane.edu.
² Department of Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
³ Section of Endocrinology and Metabolism, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.

PMID: 37499878
DOI: 10.1016/j.diabres.2023.110856

Abstract

Using two large prospective epidemiological studies in the U.S., we examined biomarkers that reflect sex-specific pathophysiological pathways to cardiovascular complications among people with pre-diabetes. Women with pre-diabetes exhibited higher levels of adipokines, while men had lower eGFR. Sex differences in lipoproteins and vascular inflammatory markers during pre-diabetes indicate sex-specific lipoprotein and inflammatory mechanisms to cardiovascular complications.

Keywords: Biomarkers; Cardiovascular complications; Pre-diabetes; Sex differences.

MeSH terms

Biomarkers
Cardiovascular Diseases* / epidemiology
Cardiovascular Diseases* / etiology
Female
Heart Diseases* / complications
Humans
Lipoproteins
Male
Prediabetic State* / complications
Prospective Studies
Risk Factors
Sex Characteristics
Sex Factors

Substances

Biomarkers
Lipoproteins