Genotyping of Helicobacter pylori CagA/CagE strains in gastric mucosa and its association with gastric illness

A Fazio; M Bitrán-Ambler; S Ramírez-Rivera; V Zaffiri; G Bernal

doi:10.1016/j.diagmicrobio.2023.116028

Genotyping of Helicobacter pylori CagA/CagE strains in gastric mucosa and its association with gastric illness

Diagn Microbiol Infect Dis. 2023 Oct;107(2):116028. doi: 10.1016/j.diagmicrobio.2023.116028. Epub 2023 Jul 15.

Authors

A Fazio¹, M Bitrán-Ambler¹, S Ramírez-Rivera¹, V Zaffiri¹, G Bernal²

Affiliations

¹ Laboratory of Molecular and Cellular Biology of Cancer (CáncerLab), Department of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile.
² Laboratory of Molecular and Cellular Biology of Cancer (CáncerLab), Department of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile. Electronic address: gbernal@ucn.cl.

PMID: 37499605
DOI: 10.1016/j.diagmicrobio.2023.116028

Abstract

The aim of this work was associate the presence of the virulence factors of Helicobacter pylori, cagA/cagE, with gastric illness. We found evidence that indicate the contribution of these genotypes with the severity of gastric lesions in patients infected, principally in histological subtypes as atrophic gastritis, and metaplasia.

Keywords: CagA+; CagE+; Helicobacter pylori; gastric diseases.

MeSH terms

Antigens, Bacterial / genetics
Bacterial Proteins / genetics
Gastric Mucosa
Genotype
Helicobacter Infections* / complications
Helicobacter pylori* / genetics
Humans

Substances

Antigens, Bacterial
Bacterial Proteins
cagA protein, Helicobacter pylori