miRNAs driving diagnosis, progression, and drug resistance in multiple myeloma

Mohamed A Elkady; Amr Mohamed Yehia; Elsayed G E Elsakka; Ahmed I Abulsoud; Nourhan M Abdelmaksoud; Ahmed Elshafei; Samy Y Elkhawaga; Ahmed Ismail; Mahmoud Mohamed Mokhtar; Hesham A El-Mahdy; Maghawry Hegazy; Mohammed S Elballal; Osama A Mohammed; Hussein M El-Husseiny; Heba M Midan; Walaa A El-Dakroury; Moataz B Zewail; Sherif S Abdel Mageed; Ahmed S Doghish

doi:10.1016/j.prp.2023.154704

miRNAs driving diagnosis, progression, and drug resistance in multiple myeloma

Pathol Res Pract. 2023 Aug:248:154704. doi: 10.1016/j.prp.2023.154704. Epub 2023 Jul 22.

Authors

Mohamed A Elkady¹, Amr Mohamed Yehia¹, Elsayed G E Elsakka¹, Ahmed I Abulsoud², Nourhan M Abdelmaksoud³, Ahmed Elshafei¹, Samy Y Elkhawaga¹, Ahmed Ismail¹, Mahmoud Mohamed Mokhtar¹, Hesham A El-Mahdy⁴, Maghawry Hegazy¹, Mohammed S Elballal⁵, Osama A Mohammed⁶, Hussein M El-Husseiny⁷, Heba M Midan⁵, Walaa A El-Dakroury⁸, Moataz B Zewail⁸, Sherif S Abdel Mageed⁹, Ahmed S Doghish¹⁰

Affiliations

¹ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
² Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
³ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
⁴ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: heshamabbas@azhar.edu.eg.
⁵ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁶ Department of Clinical Pharmacology, Faculty of Medicine, Bisha University, Bisha 61922, Saudi Arabia; Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
⁷ Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya 13736, Egypt; Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai Cho, Fuchu-shi, Tokyo 183-8509, Japan.
⁸ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁹ Department of Pharmacology & Toxicology, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
¹⁰ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg.

PMID: 37499518
DOI: 10.1016/j.prp.2023.154704

Abstract

Multiple myeloma (MM) is a tumor of transformed plasma cells. It's the second most common hematologic cancer after non-Hodgkin lymphoma. MM is a complex disease with many different risk factors, including ethnicity, race, and epigenetics. The microRNAs (miRNAs) are a critical epigenetic factor in multiple myeloma, influencing key aspects such as pathogenesis, prognosis, and resistance to treatment. They have the potential to assist in disease diagnosis and modulate the resistance behavior of MM towards therapeutic regimens. These characteristics could be attributed to the modulatory effects of miRNAs on some vital pathways such as NF-KB, PI3k/AKT, and P53. This review discusses the role of miRNAs in MM with a focus on their role in disease progression, diagnosis, and therapeutic resistance.

Keywords: Diagnosis; Drug resistance; MM; Multiple myeloma; Progression; miRNAs.

Publication types

Review

MeSH terms

Drug Resistance, Neoplasm / genetics
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs* / metabolism
Multiple Myeloma* / diagnosis
Multiple Myeloma* / drug therapy
Multiple Myeloma* / genetics
Phosphatidylinositol 3-Kinases / metabolism
Prognosis

Substances

MicroRNAs
Phosphatidylinositol 3-Kinases