Mid-infrared photoacoustic spectroscopy based on ultrasound detection for blood component analysis

Ryota Sasaki; Saiko Kino; Yuji Matsuura

doi:10.1364/BOE.494615

Mid-infrared photoacoustic spectroscopy based on ultrasound detection for blood component analysis

Biomed Opt Express. 2023 Jun 30;14(7):3841-3852. doi: 10.1364/BOE.494615. eCollection 2023 Jul 1.

Authors

Ryota Sasaki¹, Saiko Kino¹, Yuji Matsuura¹

Affiliation

¹ Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aoba, Sendai, 980-8579, Japan.

Abstract

For the non-invasive measurement of biological tissue, a piezoelectric photoacoustic spectroscopy (PZT-PAS) system that detects a single frequency of ultrasound induced by the irradiation of pulse-modulated mid-infrared laser light was developed. PA spectra of the optical phantom and biological samples were obtained, and the relationship between the PA signal intensity and optical absorbance in the fingerprint region (930-1,200 cm^-1) was analyzed to estimate the optical absorbance. The resonance vibration of the induced ultrasound was utilized to further increase the signal strength for biological tissue measurement. Consequently, PA spectrum reflecting the absorption of components in biological tissues was obtained.