Patent landscape review of non-invasive medical sensors for continuous monitoring of blood pressure and their validation in critical care practice

Olena Litvinova; Aylin Bilir; Emil D Parvanov; Josef Niebauer; Maria Kletecka-Pulker; Oliver Kimberger; Atanas G Atanasov; Harald Willschke

doi:10.3389/fmed.2023.1138051

Patent landscape review of non-invasive medical sensors for continuous monitoring of blood pressure and their validation in critical care practice

Front Med (Lausanne). 2023 Jul 11:10:1138051. doi: 10.3389/fmed.2023.1138051. eCollection 2023.

Authors

Olena Litvinova¹, Aylin Bilir², Emil D Parvanov^{2

3}, Josef Niebauer^{4

5

6}, Maria Kletecka-Pulker^{2

7}, Oliver Kimberger^{2

8}, Atanas G Atanasov^{2

9}, Harald Willschke^{2

8}

Affiliations

¹ National University of Pharmacy of the Ministry of Health of Ukraine, Kharkiv, Ukraine.
² Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria.
³ Department of Translational Stem Cell Biology, Research Institute of the Medical University of Varna, Varna, Bulgaria.
⁴ Ludwig Boltzmann Institute for Digital Health and Prevention, Salzburg, Austria.
⁵ University Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University Salzburg, Salzburg, Austria.
⁶ REHA Zentrum Salzburg, Salzburg, Austria.
⁷ Institute for Ethics and Law in Medicine, University of Vienna, Vienna, Austria.
⁸ Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
⁹ Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, Warsaw, Poland.

Abstract

Objectives: Continuous non-invasive monitoring of blood pressure is one of the main factors in ensuring the safety of the patient's condition in anesthesiology, intensive care, surgery, and other areas of medicine. The purpose of this work was to analyze the current patent situation and identify directions and trends in the application of non-invasive medical sensors for continuous blood pressure monitoring, with a focus on clinical experience in critical care and validation thereof.

Materials and methods: The research results reflect data collected up to September 30, 2022. Patent databases, Google Scholar, the Lens database, Pubmed, Scopus databases were used to search for patent and clinical information.

Results: An analysis of the patent landscape indicates a significant increase in interest in the development of non-invasive devices for continuous blood pressure monitoring and their implementation in medical practice, especially in the last 10 years. The key players in the intellectual property market are the following companies: Cnsystems Medizintechnik; Sotera Wireless INC; Tensys Medical INC; Healthstats Int Pte LTD; Edwards Lifesciences Corp, among others. Systematization of data from validation and clinical studies in critical care practice on patients with various pathological conditions and ages, including children and newborns, revealed that a number of non-invasive medical sensor technologies are quite accurate and comparable to the "gold standard" continuous invasive blood pressure monitoring. They are approved by the FDA for medical applications and certified according to ISO 81060-2, ISO 81060-3, and ISO/TS 81060-5. Unregistered and uncertified medical sensors require further clinical trials.

Conclusion: Non-invasive medical sensors for continuous blood pressure monitoring do not replace, but complement, existing methods of regular blood pressure measurement, and it is expected to see more of these technologies broadly implemented in the practice in the near future.

Keywords: blood pressure; continuous non-invasive monitoring; intensive care; validation.

Publication types

Review