Consequences of HIV infection in the bone marrow niche

Candice Lee Herd; Juanita Mellet; Tsungai Mashingaidze; Chrisna Durandt; Michael Sean Pepper

doi:10.3389/fimmu.2023.1163012

Consequences of HIV infection in the bone marrow niche

Front Immunol. 2023 Jul 11:14:1163012. doi: 10.3389/fimmu.2023.1163012. eCollection 2023.

Authors

Candice Lee Herd¹, Juanita Mellet¹, Tsungai Mashingaidze¹, Chrisna Durandt¹, Michael Sean Pepper¹

Affiliation

¹ Institute for Cellular and Molecular Medicine, Department of Medical Immunology, South African Medical Research Council (SAMRC) Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Abstract

Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions primarily in the maintenance of haematopoietic stem/progenitor cells (HSPCs). These adult stem cells are responsible for replacing blood and immune cells over the course of a lifetime. Cells of the bone marrow niche support HSPCs and help to orchestrate the quiescence, self-renewal and differentiation of HSPCs through chemical and molecular signals and cell-cell interactions. This narrative review discusses the HIV-associated dysregulation of the bone marrow niche, as well as the susceptibility of HSPCs to infection by HIV.

Keywords: HIV; bone marrow niche; dysregulation; haematopoiesis; haematopoietic stem/progenitor cell.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bone Marrow*
Cell Communication
Cell Differentiation
HIV Infections* / complications
Hematopoietic Stem Cells
Humans

Grants and funding

CH is funded by the NRF-DAAD program and the University of Pretoria. TM is funded by the National Research Foundation and the University of Pretoria. JM receives funding from the Bill and Melinda Gates Foundation (INV-022216). The group is funded by the South African Medical Research Council, and the University of Pretoria (through the ICMM).