Comparison of the short-term efficacy of different Amplatzer models and similar occluders in the treatment of patent foramen ovale

Yuxuan Lou; Yang Hua; Jing Shi; Fengze Yang; Yifei Wang; Yang Yang; Wei Sun; Xiangqing Kong; Hao Zhang

doi:10.3389/fcvm.2023.1092465

Comparison of the short-term efficacy of different Amplatzer models and similar occluders in the treatment of patent foramen ovale

Front Cardiovasc Med. 2023 Jul 11:10:1092465. doi: 10.3389/fcvm.2023.1092465. eCollection 2023.

Authors

Yuxuan Lou^#^{1

2}, Yang Hua^#¹, Jing Shi^#¹, Fengze Yang¹, Yifei Wang¹, Yang Yang¹, Wei Sun¹, Xiangqing Kong^{1

2}, Hao Zhang¹

Affiliations

¹ Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
² Southeast University School of Medicine, Nanjing, China.

^# Contributed equally.

Abstract

Objective: To compare the recent efficacy and safety of different Amplatzer models and similar occluder in the treatment of patent foramen ovale (PFO).

Methods: Patients with PFO complicated with cryptogenic stroke or migraine who underwent transcatheter closure of PFO in the First Affiliated Hospital of Nanjing Medical University from September 2019 to March 2021 were selected. Patients were grouped according to the type of occluder device. The basic data of the patients were collected and followed up within 1 year after occlusion. Effectiveness was defined as no recurrence of stroke/remission of migraine symptoms and a negative postoperative foaming test, and safety events were counted as the combined results of serious adverse events.

Results: A total of 92 patients were selected, including 45 cases in the symmetrical group and 47 cases in the asymmetric group. There were no serious adverse events in the 2 groups during follow-up. 3 days and 1 month after occlusion, the number of shunt patients in the asymmetric group was significantly less than that in the symmetric group (χ² = 5.484, P = 0.019; χ² = 5.146, P = 0.023). The negative rate of blocked residual shunts in the asymmetric group was higher than that in the symmetric group at 1, 3, 6 and 12 months after occlusion (χ² = 6.473, P = 0.011; χ² = 4.305, P = 0.038; χ² = 4.842, P = 0.027; χ² = 4.034, P = 0.045). Headache in migraine patients in the asymmetric group was significantly better than headache in patients in the symmetric group (P = 0.038; P = 0.049).

Conclusion: Asymmetric Amplatzer and similar occluders provide greater efficacy in short-term occlusion than symmetric ones.

Keywords: Amplatzer occluder; closure; cryptogenic stroke; migraine; patent foramen ovale.

Grants and funding

This work was conducted at the First Affiliated Hospital of Nanjing Medical University, and was funded by the Clinical Capacity Improvement Project Fund (JSPH-MB-2020-7). We are grateful to Yunfan Tian for his help in analyzing the data. We would also like to thank Jing Shi for helping me complete this paper. His profound knowledge of English inspired my love for this beautiful language.