MiR-34a and endothelial biology

Qiuxia Li; Quanjiang Zhang

doi:10.1016/j.lfs.2023.121976

MiR-34a and endothelial biology

Life Sci. 2023 Oct 1:330:121976. doi: 10.1016/j.lfs.2023.121976. Epub 2023 Jul 24.

Authors

Qiuxia Li¹, Quanjiang Zhang²

Affiliations

¹ Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine and UCLA Health, University of California-Los Angeles, Los Angeles, CA 90095, USA; Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address: qiuxiali@mednet.ucla.edu.
² Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine and UCLA Health, University of California-Los Angeles, Los Angeles, CA 90095, USA. Electronic address: quanjiangzhang@mednet.ucla.edu.

PMID: 37495076
DOI: 10.1016/j.lfs.2023.121976

Abstract

MicroRNAs (miRNAs) are endogenous ∼22 nt long RNAs that play important gene-regulatory roles in cells by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. Many miRNAs have been identified in endothelial cells and play important roles in endothelial biology. miR-34a is relatively early identified in endothelial cells and has been involved in regulating endothelial functions, angiogenesis, differentiation, senescence, inflammatory response, responses to shear stress, and mitochondrial function. This review outlines the current understanding of miR-34a in endothelial biology and discusses its potential as a therapeutic target to treat vascular diseases.

Keywords: Endothelial biology; Endothelial cells; Signal transduction; Vascular diseases; miR-34a.

Publication types

Review

MeSH terms

Biology
Cell Differentiation
Endothelial Cells*
Gene Expression Regulation
MicroRNAs* / genetics

Substances

MicroRNAs