THE EFFECT OF BOTULINUM TOXIN TYPE A IN PATIENTS WITH ESSENTIAL BLEPHAROSPASM

Acta Clin Croat. 2022 Nov;61(3):379-385. doi: 10.20471/acc.2022.61.03.02.

Abstract

The aim of this study was to determine the effect of botulinum toxin type A and satisfaction in patients with essential blepharospasm. The study included 12 subjects suffering from essential blepharospasm who received therapy with botulinum toxin type A injections. Respondents were given a Blepharospasm Disability Index (BSDI) survey before and three weeks after the procedure with questions related to quality of life. They were also given a Jankovic Rating Scale with questions related to the severity and frequency of symptoms. The overall level of difficulties was reduced, meaning the quality of life increased after the application of botulinum toxin, and the study found that the increase was statistically significant (p = 0.003). The severity of symptoms after the application of botulinum toxin was reduced, which meant that there was a decrease in the severity of the difficulties, and the study found a statistically significant difference (p=0.003). The frequency of symptoms was reduced after botulinum toxin administration, and the study revealed a statistically significant difference (p = 0.012). From the results of this study, we can determine that the use of botulinum toxin type A increases the quality of life and that the severity and frequency of symptoms are statistically significantly reduced.

Keywords: Blepharospasm Disability Index; Jankovic Rating Scale; dystonia; essential blepharospasm; notulinum toxin type A.

MeSH terms

  • Blepharospasm* / drug therapy
  • Botulinum Toxins, Type A* / therapeutic use
  • Humans
  • Neuromuscular Agents* / therapeutic use
  • Quality of Life

Substances

  • Botulinum Toxins, Type A
  • Neuromuscular Agents

Supplementary concepts

  • Benign essential blepharospasm