An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats

Sien Lin; Hirotsugu Maekawa; Seyedsina Moeinzadeh; Elaine Lui; Hossein Vahid Alizadeh; Jiannan Li; Sungwoo Kim; Michael Poland; Benjamin C Gadomski; Jeremiah T Easley; Jeffrey Young; Michael Gardner; David Mohler; William J Maloney; Yunzhi Peter Yang

doi:10.1038/s41467-023-40149-5

An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats

Nat Commun. 2023 Jul 24;14(1):4455. doi: 10.1038/s41467-023-40149-5.

Authors

Sien Lin^#¹, Hirotsugu Maekawa^#¹, Seyedsina Moeinzadeh¹, Elaine Lui^{1

2}, Hossein Vahid Alizadeh¹, Jiannan Li¹, Sungwoo Kim¹, Michael Poland³, Benjamin C Gadomski³, Jeremiah T Easley⁴, Jeffrey Young¹, Michael Gardner¹, David Mohler¹, William J Maloney¹, Yunzhi Peter Yang^{5

6

7}

Affiliations

¹ Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
² Department of Mechanical Engineering, School of Engineering, Stanford University, Stanford, CA, 94305, USA.
³ Orthopaedic Bioengineering Research Laboratory, Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, 80523, USA.
⁴ Preclinical Surgical Research Laboratory, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
⁵ Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA, 94305, USA. ypyang@stanford.edu.
⁶ Department of Materials Science and Engineering, School of Engineering, Stanford University, Stanford, CA, 94305, USA. ypyang@stanford.edu.
⁷ Department of Bioengineering, School of Medicine, Stanford University, Stanford, CA, 94305, USA. ypyang@stanford.edu.

^# Contributed equally.

Abstract

Bone transport is a surgery-driven procedure for the treatment of large bone defects. However, challenging complications include prolonged consolidation, docking site nonunion and pin tract infection. Here, we develop an osteoinductive and biodegradable intramedullary implant by a hybrid tissue engineering construct technique to enable sustained delivery of bone morphogenetic protein-2 as an adjunctive therapy. In a male rat bone transport model, the eluting bone morphogenetic protein-2 from the implants accelerates bone formation and remodeling, leading to early bony fusion as shown by imaging, mechanical testing, histological analysis, and microarray assays. Moreover, no pin tract infection but tight osseointegration are observed. In contrast, conventional treatments show higher proportion of docking site nonunion and pin tract infection. The findings of this study demonstrate that the novel intramedullary implant holds great promise for advancing bone transport techniques by promoting bone regeneration and reducing complications in the treatment of bone defects.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Absorbable Implants*
Animals
Biological Assay
Bone Regeneration
Male
Osseointegration
Osteogenesis*
Rats

Abstract

Publication types

MeSH terms

Grants and funding