Prognostic scores for patients with salivary adenoid cystic carcinoma without lymph node metastasis

Hikari Shimoda; Masanori Teshima; Takayuki Murase; Toshitaka Nagao; Kimihide Kusafuka; Masato Nakaguro; Makoto Urano; Ken-Ichi Taguchi; Hidetaka Yamamoto; Satoshi Kano; Yuichiro Tada; Kiyoaki Tsukahara; Kenji Okami; Tetsuro Onitsuka; Yasushi Fujimoto; Daisuke Kawakita; Kazuo Sakurai; Nobuhiro Hanai; Toru Nagao; Ryo Kawata; Naohito Hato; Ken-Ichi Nibu; Hiroshi Inagaki

doi:10.1016/j.oraloncology.2023.106491

Prognostic scores for patients with salivary adenoid cystic carcinoma without lymph node metastasis

Oral Oncol. 2023 Oct:145:106491. doi: 10.1016/j.oraloncology.2023.106491. Epub 2023 Jul 22.

Authors

Hikari Shimoda¹, Masanori Teshima², Takayuki Murase³, Toshitaka Nagao⁴, Kimihide Kusafuka⁵, Masato Nakaguro⁶, Makoto Urano⁷, Ken-Ichi Taguchi⁸, Hidetaka Yamamoto⁹, Satoshi Kano¹⁰, Yuichiro Tada¹¹, Kiyoaki Tsukahara¹², Kenji Okami¹³, Tetsuro Onitsuka¹⁴, Yasushi Fujimoto¹⁵, Daisuke Kawakita¹⁶, Kazuo Sakurai¹⁷, Nobuhiro Hanai¹⁸, Toru Nagao¹⁹, Ryo Kawata²⁰, Naohito Hato²¹, Ken-Ichi Nibu²², Hiroshi Inagaki²³

Affiliations

¹ Department of Otolaryngology‑Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
² Department of Otolaryngology‑Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
³ Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
⁴ Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
⁵ Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.
⁶ Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
⁷ Department of Diagnostic Pathology, Bantane Hospital, Fujita Health University School of Medicine, Nagoya, Japan.
⁸ Department of Pathology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
⁹ Department of Anatomic Pathology, Graduate of School of Medical Science, Kyushu University, Fukuoka, Japan.
¹⁰ Department of Otolaryngology‑Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
¹¹ Department of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
¹² Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
¹³ Department of Otolaryngology‑Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
¹⁴ Division of Head and Neck Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
¹⁵ Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Otorhinolaryngology-Head and Neck Surgery, Aichi Medical University School of Medicine, Nagakute, Japan.
¹⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
¹⁷ Department of Otorhinolaryngology, Fujita Health University, Okazaki Medical Center, Okazaki, Japan.
¹⁸ Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
¹⁹ Department of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
²⁰ Department of Otorhinolaryngology‑Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
²¹ Department of Otolaryngology, Ehime University School of Medicine, Toon, Japan.
²² Department of Otolaryngology‑Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: nibu@med.kobe-u.ac.jp.
²³ Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: hinagaki@med.nagoya-cu.ac.jp.

PMID: 37487445
DOI: 10.1016/j.oraloncology.2023.106491

Abstract

Adenoid cystic carcinoma (AdCC) of salivary gland grows relatively slowly, but occasionally develops distant metastasis. Although cervical lymph node metastasis (LNM) has been reported as a strong prognostic factor, most of AdCC do not have LNM. In this study, we investigated the prognostic factors to predict disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS) for 175 patients surgically treated for AdCC without LNM, and developed prognostic score (PS) determined as number of positive prognostic factors. The following emerged as significant prognostic factors: positive surgical margin in DFS, pT3/4 and positive surgical margin in DMFS, and positive surgical margin and high-histological grade in OS. 10-year DFS rates were 56.4% in PS0, and 19.1% in PS1 (p < 0.0001). 10-year DMFS rates were 86.3% in PS0, 56.4% in PS1, and 30.7% in PS2 (p < 0.0001). 10-year OS rates were 100% in PS0, 73.3% in PS1, and 38.8% in PS2 (p < 0.0001).

Keywords: And distant metastasis; Lymph node metastasis; Surgical margin; minAmax; pT.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Adenoid Cystic* / pathology
Humans
Lymph Nodes / pathology
Lymphatic Metastasis / pathology
Margins of Excision
Neoplasm Recurrence, Local / pathology
Neoplasm Staging
Prognosis
Retrospective Studies
Salivary Gland Neoplasms* / pathology