Mycobacterium shinjukuense infection successfully treated with clarithromycin, rifampicin, and ethambutol

Kayo Nakamura; Etsuko Murakami; Daizo Kishino; Shuko Mashimo; Yusuke Kurioka; Yusaku Shibata; Arihiko Taniguchi; Hisao Higo; Yasushi Hiramatsu; Yoshinobu Maeda; Nobuaki Miyahara

doi:10.1016/j.rmcr.2023.101894

Mycobacterium shinjukuense infection successfully treated with clarithromycin, rifampicin, and ethambutol

Respir Med Case Rep. 2023 Jul 8:45:101894. doi: 10.1016/j.rmcr.2023.101894. eCollection 2023.

Authors

Kayo Nakamura¹, Etsuko Murakami¹, Daizo Kishino¹, Shuko Mashimo¹, Yusuke Kurioka¹, Yusaku Shibata¹, Arihiko Taniguchi^{2

3}, Hisao Higo^{2

3}, Yasushi Hiramatsu¹, Yoshinobu Maeda³, Nobuaki Miyahara^{1

2

4}

Affiliations

¹ Department of Medicine, Japanese Red Cross Society Himeji Hospital, Japan.
² Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan.
³ Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
⁴ Department of Medical Technology, Okayama University Graduate School of Health Sciences, Japan.

Abstract

We present the case of a 59-year-old woman diagnosed with Mycobacterium shinjukuense infection using mass spectrometry of bronchioalveolar lavage fluid. We initiated treatment with clarithromycin, rifampicin, and ethambutol based on the results of drug susceptibility testing, which improved lung opacities. Most previous cases were treated with the standard regimen for Mycobacterium tuberculosis. However, our regimen may provide a therapeutic option for this rare nontuberculous Mycobacterium infection.

Keywords: Clarithromycin; Mycobacterium shinjukuense; Mycobacterium tuberculosis; Nontuberculous mycobacterium.

Publication types

Case Reports