Multisystem Inflammatory Syndrome: A Case in an Adult With Controlled Lymphoma and a Persistent SARS-CoV-2 Infection

Luca Pipitò; Alice Medaglia; Irene Russotto; Silvia Bonura; Antonio Cascio

doi:10.7759/cureus.40776

Multisystem Inflammatory Syndrome: A Case in an Adult With Controlled Lymphoma and a Persistent SARS-CoV-2 Infection

Cureus. 2023 Jun 22;15(6):e40776. doi: 10.7759/cureus.40776. eCollection 2023 Jun.

Authors

Luca Pipitò^{1

2}, Alice Medaglia¹, Irene Russotto^{1

2}, Silvia Bonura¹, Antonio Cascio^{1

2}

Affiliations

¹ Department of Infectious and Tropical Diseases, Azienda Ospedaliera Universitaria Policlinico (AOUP) Paolo Giaccone, Palermo, ITA.
² Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, ITA.

Abstract

Multisystem inflammatory syndrome (MIS) is a new and rare complication of COVID-19 that usually occurs in children. An increasing number of cases of MIS in adults are described in the literature. The condition is associated with high mortality, and treatment is non-standardized. Clinical pictures are heterogeneous, and diagnosis is very challenging. Here we describe a case of MIS in a 60-year-old man with previous follicular lymphoma treated with obinutuzumab and recent SARS-CoV-2 infections. He complained of an unknown fever and developed pancytopenia during the hospitalization, associated with a general clinical worsening. The patient was successfully treated with intravenous immunoglobulin and steroids.

Keywords: fever of unknown; multisystem inflammatory syndrome; pancytopenia; pericardial effusion; sars-cov-2 persistence.

Publication types

Case Reports