Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential

Himanshu Arora

doi:10.1016/j.molmed.2023.06.010

Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential

Trends Mol Med. 2023 Nov;29(11):880-882. doi: 10.1016/j.molmed.2023.06.010. Epub 2023 Jul 21.

Author

Himanshu Arora¹

Affiliation

¹ Desai Sethi Institute of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: Hxa287@miami.edu.

PMID: 37482452
DOI: 10.1016/j.molmed.2023.06.010

Abstract

Leptin, an adipokine hormone, is a critical regulator of energy homeostasis, appetite, and metabolism. Recent advances have elucidated its role in male fertility. This forum provides an overview of the interplay between leptin, its receptors, and signaling pathways in the context of male fertility, revealing its multifaceted impact on reproductive health.

Keywords: Leydig cell; androgen deficiency; leptin; male infertility; testis; testosterone.